Unravelling the physico-chemical mechanisms behind collagen formation and the process of collagen mineralisation

About the Project

Collagen is a key protein in mammals providing the basis for connective tissue, bone, teeth and other important components of the body. Its hierarchical organisation is enabling the formation of materials with unique mechanical and optical properties and its self-similar assembly over many length scales makes it an intriguing object of studies. Some fundamental properties of this polymer forming molecule and its quasi-crystalline patterns are still astonishingly poorly understood both from the theoretical and the experimental perspective.

In this project advanced high-resolution electron microscopy in conjunction with Raman spectroscopy, informed by mathematical physics, will be used to obtain quantitative information on the molecular interactions leading to the characteristic organisation patterns across the length scales. This information will be at the centre of the development of a model of collagen assembly leading to the creation of matrices, which can act as templates for mineralisation.

A background in materials physics and/or chemistry is highly desirable as well as a strong interest in bringing together experimental evidence and theoretical modelling. The emphasis of this project will be on the experimental side and skills will be obtained in advanced electron microscopy (EM), such as liquid cell transmission EM and Raman spectroscopy. Furthermore, this work aligns with ongoing collaborations with the Diamond Light Source making use of synchrotron based characterisation techniques to reveal the structure and dynamics of collagen and its formation as well as its mineralisation by calcium phosphate.

How to Apply:

Applicants should apply via the University’s online application system at https://www.york.ac.uk/study/postgraduate-research/apply/. Please read the application guidance first so that you understand the various steps in the application process.