Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Campuses

DZNE Berlin, integrated with Charité, emphasizes clinical and imaging-focused courses on Alzheimer's and Parkinson's diseases, offering PhD programs and specialized training.

• Advanced neuroimaging and fluid biomarkers
• Clinical phenotyping and longitudinal studies
• Genetics of late-onset dementia
• Neuroinflammation in disease progression
• Patient-derived iPSC models
• AI in neuroimaging analysis
• Multimodal biomarker validation
• Cohort studies like AgeCoDe
• Therapeutic interventions and trials
• Neuropsychology assessments

Seminars with Charité faculty cover translational aspects. Workshops on ethical clinical research and data management are standard. The site supports international exchanges and masterclasses on precision medicine in neurology.

Training integrates hospital settings for real-world application, preparing students for clinical research careers. Collaborative programs with Humboldt University enhance epidemiological training.

The DZNE Bonn campus, as the headquarters, specializes in advanced research training and educational programs on neurodegenerative diseases including Alzheimer's, Parkinson's, frontotemporal dementia, and ALS. It hosts the DZNE Graduate Program offering structured PhD training with interdisciplinary courses.

• Molecular mechanisms of protein aggregation and clearance
• Genetics and genomics of familial and sporadic neurodegeneration
• Neuroimaging techniques including PET, MRI, and tau-PET
• Clinical trial design and biomarker development
• Stem cell modeling using iPSCs for disease modeling
• Bioinformatics and big data analysis in neuroscience
• Epidemiology of population-based cohorts like DELCODE
• Neuroimmunology and glial cell contributions
• Therapeutic strategies including gene therapy and immunotherapy
• Pathophysiology of synaptic dysfunction

Regular seminars, journal clubs, and workshops cover cutting-edge topics. International summer schools on neurodegeneration attract global researchers. Postdoctoral training emphasizes grant writing and career development. Collaborative courses with University of Bonn integrate basic and clinical neuroscience, fostering translational research. Hands-on lab rotations and ethics training ensure comprehensive skill-building for future leaders in the field.

Approximately 300 words describing the rigorous curriculum focused on combating neurodegenerative diseases through innovative education and research integration.

DZNE Dresden focuses on stem cell biology and regenerative medicine courses for neurodegenerative disorders, part of the DRESDEN-concept cluster.

• Human iPSC derivation and neuronal differentiation
• CRISPR genome editing in disease models
• 3D organoid cultures for brain modeling
• Regenerative therapies for PD and HD
• High-content screening platforms
• Single-cell RNA sequencing
• Proteostasis and autophagy mechanisms
• Neural circuit analysis
• Translational stem cell applications
• Bioengineering of neural tissues

PhD training via IMPRS-CellDevoSys includes lab courses and retreats. Workshops on advanced microscopy and optogenetics are offered regularly.

Emphasis on technology development supports interdisciplinary education with TU Dresden, aiming at novel therapies.

DZNE Göttingen excels in courses on protein misfolding, proteostasis, and lysosomal function in neurodegeneration.

• Autophagy-lysosome pathway dysregulation
• Alpha-synuclein and tau pathology
• Endosomal trafficking defects
• Structural biology of aggregates
• Mouse and fly models of disease
• High-throughput proteomics
• Chaperone-mediated clearance
• Mitochondrial dynamics
• Therapeutic modulation of proteostasis
• Imaging of protein aggregates

Integrated with Max Planck Institute, offers joint graduate programs with hands-on model organism courses. Seminars on synaptic biology and retreats foster collaboration.

Training prepares for academia and industry in molecular neuroscience.

DZNE Hamburg, at UKE, specializes in genetic and epidemiological courses on dementia and movement disorders.

• Whole-genome sequencing analysis
• Population genetics of AD and PD
• Longitudinal cohort studies
• Risk factor epidemiology
• Polygenic risk scores
• Functional genomics
• Clinical genetics counseling
• Deep phenotyping protocols
• Biobanking and omics integration
• Preventive strategies

PhD courses with University Medical Center Hamburg-Eppendorf include stats and ethics. Workshops on NGS data handling are key.

Focus on translational genetics bridges research to patient care.

DZNE Köln targets courses on neuroinflammation, glia, and myelination in neurodegeneration.

• Microglia activation mechanisms
• Astrocyte-neuron interactions
• Oligodendrocyte dysfunction
• Inflammatory signaling pathways
• Animal models of neuroinflammation
• Cytokine profiling
• Immune-modulatory therapies
• White matter pathology
• Glial heterogeneity scRNA-seq
• Blood-brain barrier alterations

Collaborative training with University of Cologne features imaging workshops and glial cell culture courses.

Emphasizes immune contributions to disease progression.

DZNE Leipzig offers courses on vascular contributions and multimodality imaging in dementia.

• Cerebral small vessel disease
• Neurovascular coupling
• Multimodal MRI/PET imaging
• White/gray matter lesion analysis
• Population imaging cohorts
• AI for image processing
• Hypoxia and vascular risk factors
• Longitudinal imaging protocols
• Biomarker correlations
• Intervention studies

Training with Leipzig University includes computational neuroscience modules and data science bootcamps.

Focuses on vascular-dementia interface.

DZNE Magdeburg specializes in computational modeling and systems neuroscience courses for neurodegeneration.

• Neural network simulations
• Cognitive modeling of memory decline
• Connectome analysis
• Machine learning for disease prediction
• EEG/MEG signal processing
• Brain-computer interfaces
• Systems biology of circuits
• Behavioral phenotyping
• Virtual reality paradigms
• Data-driven hypothesis testing

Joint programs with Otto von Guericke University feature programming workshops and model validation courses.

Bridges computation and experiment.

DZNE München focuses on courses in movement disorders genetics and clinical cohorts.

• Genetics of atypical parkinsonism
• LRRK2 and GBA pathways
• Deep brain stimulation modeling
• Digital biomarkers for gait
• Population cohorts like LANDMARK
• Alpha-synuclein PET imaging
• Therapeutic development
• Neuropathology correlations
• Biophysical modeling
• Personalized medicine

Training with LMU/TUM includes clinical trial courses and movement analysis labs.

Strong emphasis on Parkinson's spectrum.

DZNE Rostock/Greifswald offers courses on ALS, FTD, and protein homeostasis.

• RNA metabolism in ALS/FTD
• TDP-43 pathology
• Motor neuron disease models
• Proteotoxic stress responses
• Patient registries
• Exosome biomarkers
• Gene therapy vectors
• Neuromuscular junction analysis
• Transcriptomics
• Clinical trial endpoints

Collaborations with Rostock and Greifswald Universities provide wet-lab and clinical training.

Targets motor and frontotemporal disorders.

DZNE Tübingen emphasizes courses on sensory neurodegeneration, optogenetics, and circuit neuroscience.

• Retinal degeneration models
• Optogenetic manipulation
• Viral vector engineering
• Synaptic vesicle dynamics
• Two-photon imaging
• Behavior in disease models
• Gene delivery systems
• Neural circuit mapping
• Therapeutic optogenetics
• High-res imaging techniques

Integrated with Hertie Institute, offers advanced microscopy and electrophysiology courses.

Focuses on vision and motor circuits in disease.