The Duke-NUS Medical School Main Campus, housed in the Khoo Teck Puat Building, specializes in graduate-entry medical education and translational biomedical research. As a collaboration between Duke University and the National University of Singapore, it delivers a world-class Doctor of Medicine (MD) program modeled on Duke's innovative curriculum, emphasizing clinician-scientist training through integrated phases of basic sciences, clinical clerkships, mentored research, and advanced electives. The campus supports PhD and MD-PhD tracks across signature research programs addressing Singapore's and global health priorities, leveraging its location in the SingHealth Duke-NUS Academic Medical Centre for close ties to clinical practice.
Over 15 academic clinical departments, including Anaesthesiology, Emergency Medicine, Oncology, Paediatrics, and Surgery, provide specialized training and research opportunities. Executive education via the Centre for Lifelong Learning offers master's in healthcare leadership and short courses in medical affairs and patient safety.