María Lionza - A prominent figure in Venezuelan folklore, often associated with the university for her cultural impact.
José Gregorio Hernández - A Venezuelan physician and philanthropist, known for his contributions to medicine and his beatification process.
Andrés Bello - Although not a direct alumnus, his influence on education in Venezuela is significant, and he is often linked to UNESR for his educational reforms.
Teresa de la Parra - A renowned Venezuelan novelist, her works are studied at UNESR, reflecting her impact on literature.