Rate My Professor Alexander Khromykh

Khromykh's research specializes in the molecular pathogenesis of positive-strand RNA viruses, focusing on flaviviruses including West Nile virus, Zika virus, dengue virus, and Japanese encephalitis virus, as well as SARS-CoV-2. His laboratory investigates virus replication mechanisms, host-virus interactions, immune evasion strategies such as interferon signaling inhibition and noncoding subgenomic flavivirus RNAs, viral pathogenesis, and development of replicon-based vaccines, chimeric insect-specific flaviviruses, and antiviral therapies. He has received NHMRC Senior Research Fellowships in 2004, 2009, and 2014, along with a 2008 Long-term Invitation Fellowship from the Japanese Society for the Promotion of Science. Key publications include "A broadly protective antibody that targets the flavivirus NS1 protein" (Science, 2021), "Determinants of Zika virus host tropism uncovered by deep mutational scanning" (Nature Microbiology, 2019), "A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus" (Science Translational Medicine, 2019), "Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes" (Nature Communications, 2020), and "A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses" (Nature Communications, 2021). With over 150 publications in high-impact journals, his contributions have significantly influenced flavivirus vaccine development and antiviral research.