Alexandra Sharland

Associate Professor Alexandra Sharland holds the position of Associate Professor in the Faculty of Medicine and Health at the University of Sydney, where she is based in the Central Clinical School and affiliated with the Charles Perkins Centre. She possesses qualifications including MB BS, PhD, and FRACP. Sharland leads the Transplantation Immunobiology Group and coordinates the SURG5021 Transplantation Immunobiology unit in the Sydney Medical School. Her research specializes in transplantation immunobiology, focusing on mechanisms of transplant tolerance induction, the role of self-peptide repertoires in alloreactive CD8+ T cell recognition, molecular targets of allograft rejection, and therapeutic strategies such as gene therapy and regulatory T cells.

Key publications from her extensive body of work, which has accumulated over 2,300 citations, include 'The self-peptide repertoire plays a critical role in transplant tolerance induction' (Journal of Clinical Investigation, 2021), 'Screening self-peptides for recognition by mouse alloreactive CD8+ T cells using direct ex vivo multimer staining' (Star Protocols, 2023), 'Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells' (Frontiers in Transplantation, 2025), 'Sequestration of tissue-resident alloreactive T cells after intrahepatic activation contributes to tolerance induction' (2024), 'Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4CD25 Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor' (2021), and 'Are Induced/altered Self-peptide Antigens Responsible for De Novo Autoreactivity in Transplantation?' (2023). Recent contributions extend to clinically relevant mouse models for reduced-intensity conditioning in allogeneic hematopoietic stem cell transplantation (2025) and investigations into ischaemic endothelial necroptosis in COVID-19 angiopathy (2025). Her studies have pinpointed molecular targets for transplant rejection monitoring and advanced understanding of immune responses in organ transplantation.

Professional Email: alexandra.sharland@sydney.edu.au