Rate My Professor Anna Wiles

Dr Anna Wiles serves as a Senior Professional Practice Fellow and Research Fellow in the Department of Medical Laboratory Science within the University of Otago's Division of Health Sciences. She holds a PhD and is also affiliated with the Department of Pathology in Dunedin. Her research centers on cancer cell biology, encompassing projects with the Cell Transformation Group, Primary Cilia Research Group, Developmental Genetics Group, and Pathogenesis Group at the Dunedin School of Medicine. Wiles demonstrates proficiency in a variety of laboratory techniques, including tissue culture, flow cytometry, Western blotting, PCR, cloning, transfection, immunocytochemistry, confocal microscopy, and data analysis. Her contributions extend to investigations into p53 isoforms, telomere profiles in tumors, fibroblast activation in rheumatoid arthritis, and glioma survival factors.

Key publications by Dr Wiles include 'Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis' (2023, Arthritis Research & Therapy), 'The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer' (2019, Cell Death & Disease), 'A mouse model of the Δ133p53 isoform: roles in cancer progression and inflammation' (2018, Mammalian Genome), 'Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling' (2018, Nature Communications), 'An Δ133p53-like isoform drives exaggerated immune responses to promote chronic inflammation' (2019, European Journal of Immunology), 'Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma' (2016), 'Increased paired box transcription factor 8 has a survival function in Glioma' (2014), 'The CDKN2A G500 Allele Is More Frequent in GBM Patients' (2011), 'PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma' (2008), and 'Prognostic Association of YB-1 Expression in Breast Cancers' (2011). Her scholarly output totals 36 publications with over 670 citations, reflecting her influence in molecular cell biology and cancer research.