Biology of ageing: investigating the effect of novel compounds on longevity and functionality

About the Project

One of the primary goals of ageing research is to identify compounds that can extend lifespan and/or improve physical and cognitive performance in old age. Research over the past two decades has revealed a remarkable conservation of genetic pathways and biochemical processes that regulate lifespan across organisms ranging from yeast and worms to flies and humans. In particular, the fruit fly Drosophila has emerged as a leading model for studying both normal and pathological ageing, with roughly 75% of human disease-related genes having counterparts in the fly. Key advantages of Drosophila include their relatively low cost, ease of use, and the availability of powerful tools for genetic manipulation.

Our Department has recently identified several compounds with potential pro-longevity effects. This project aims to assess their impact during healthy ageing and in various Drosophila models of human disease. Initial lifespan studies will be complemented by a suite of molecular, biochemical, imaging, and functional analyses in flies, with subsequent studies extending to additional model systems such as zebrafish and mice.

Entry Requirements: Candidates are expected to hold (or be about to obtain) a minimum upper second-class honours degree (or equivalent) in a related area /subject. Candidates with experience in molecular biology, biochemistry, computational modelling, electrophysiology or Drosophila genetics are particularly encouraged to apply.

References

B. Zhang, E. Dunn, R.S.B. Williams, S. Snowden, H. Augustin: Decanoic acid extends lifespan and modulates metabolism in models of PLA2G6-associated neurodegeneration. Disease Models and Mechanisms, 2025). Link.

E. Dunn, B. Zhang, V. Sahota, H. Augustin: Potential benefits of medium chain fatty acids in aging and neurodegenerative disease. Review (Front. Aging Neurosci., 2023). Link.