UQ Malignant Hyperthermia Test: 1,000x Less Tissue | AcademicJobs
Discover how University of Queensland scientists have revolutionized malignant hyperthermia testing, slashing tissue needs by 1,000 times for safer, scar-free diagnosis.
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Dr Daniel Singh is a Postdoctoral Research Fellow in the School of Biomedical Sciences within the Faculty of Health, Medicine and Behavioural Sciences at the University of Queensland. He holds a Doctor of Philosophy from the University of Queensland, with his thesis titled Ryanodine receptor calcium regulation in healthy and compromised skeletal muscle completed in 2021. Dr Singh is a member of the Launikonis Group focused on muscle research and is available for supervision of higher degree research students.
His research centres on calcium regulation in skeletal muscle, including the role of ryanodine receptors in excitation-contraction coupling, store-operated calcium entry, and related processes in both healthy and compromised muscle states such as dystrophic mdx mouse models and malignant hyperthermia. Key publications include the 2026 paper Ryanodine Receptor Ca2+ Leak-Induced Redistribution of Ca2+ in Dystrophic mdx Mouse Muscle in Acta Physiologica, the 2026 paper Single muscle fibre calcium wave frequency assay for malignant hyperthermia diagnosis: an exploratory validation study in Anesthesiology, the 2023 paper Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals in Proceedings of the National Academy of Sciences, and earlier works such as the 2021 paper Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle in Science Advances. He has contributed to collaborative projects on RyR-targeted drug discovery and received past funding through an EMHG Young Investigator Research Grant in 2021 for validation of a novel malignant hyperthermia diagnostic assay. Dr Singh has served as an associate advisor on PhD projects examining RyR modifications and mitochondrial calcium handling.
Discover how University of Queensland scientists have revolutionized malignant hyperthermia testing, slashing tissue needs by 1,000 times for safer, scar-free diagnosis.