Rate My Professor Darren Newton

Dr Darren Newton is a Lecturer in Haematology and Immunology at the University of Leeds School of Medicine. He graduated with a BSc in Molecular Biology from the University of Liverpool in 1993 and completed a PhD in Immunology at the same institution, where his doctoral research investigated T cell signalling, with particular emphasis on the expression of the signalling molecule CD3-zeta. In 2002 he moved to the University of Leeds to take up a postdoctoral position in the laboratory of Professor Simon Carding, focusing on the role of gamma delta T cells in infection. He joined the Haematological Malignancy Diagnostic Service and the Section of Experimental Haematology in 2007 as a Research Fellow, progressing to Senior Tenure-Track Research Fellow before his current appointment as Lecturer. Dr Newton leads the Clonal Evolution group and maintains active research programmes in paroxysmal nocturnal haemoglobinuria and chronic lymphocytic leukaemia. His investigations include the development of in vitro bone marrow culture systems, assessment of clonality using next generation sequencing, studies of complement inhibition, and evaluation of biomarkers associated with patient outcomes. The group also houses the PNH Research Tissue Bank. Additional work addresses rare mutation detection in CLL, treatment resistance mechanisms involving TP53 and Btk, and immune repertoire sequencing to define T cell repertoires in PNH and to serve as biomarkers in myeloma and CLL. He continues collaborative research on gamma delta T cells in entheseal inflammation. Dr Newton contributes to teaching undergraduate medical students through Research Evaluation and Special Studies and Essential Medical Science modules, and delivers lectures on immunology in postgraduate MSc programmes within the School of Medicine.