Giles Duffield

Giles Duffield is an Associate Professor in the Department of Biological Sciences at the University of Notre Dame. He received his Ph.D. from the University of Cambridge in 1998. Before his appointment at Notre Dame, Duffield served as a Wellcome Trust Research Fellow and Royal Society University Research Fellow, conducting postdoctoral and faculty research at Dartmouth Medical School and Imperial College London.

Duffield's research centers on the molecular biology of circadian rhythms in mammals and mosquito vectors, elucidating the circadian clock's regulation of 24-hour endogenous rhythms in gene expression, biochemistry, physiology, and behavior across eukaryotic organisms. His laboratory employs molecular, genomic, cellular, physiological, and behavioral techniques to study vertebrate models such as mice and mammalian tissue cultures, as well as invertebrate models like Anopheles gambiae. This work addresses circadian dysfunction in human health conditions including Seasonal Affective Disorder, shift-work-associated sleep and metabolic disorders such as obesity and diabetes, and develops strategies for malaria vector control. Funding supports these efforts from the National Institute of General Medical Sciences, American Heart Association, Indiana Clinical and Translational Sciences Institute, University of Notre Dame Eck Institute for Global Health, University of Notre Dame Center for Rare and Neglected Diseases, and previously the Royal Society, Wellcome Trust, and NIMH. Key publications include "Targeted disruption of the Inhibitor of DNA binding 4 (Id4) gene alters photic entrainment of the circadian clock" (International Journal of Molecular Sciences, 2021), "Artificial light at night increases Aedes aegypti mosquito biting behavior with implications for arboviral disease transmission" (American Journal of Tropical Medicine & Hygiene, 2020), "Inhibitor of DNA binding 2 (Id2) regulates photic entrainment responses in mice" (Journal of Biological Rhythms, 2020), "Guidelines for genome-scale analysis of biological rhythms" (Journal of Biological Rhythms, 2017), and "Diel flight activity of wild-caught Anopheles farauti (s.s.) and An. hinesorum malaria mosquitoes from northern Queensland, Australia" (Parasites & Vectors, 2019).

Professional Email: gduffiel@nd.edu