T Cells Secrete DNA for Cancer Immunity | Weill Cornell Study | AcademicJobs
Weill Cornell researchers discover how T cells secrete DNA-laden extracellular vesicles to enhance antigen presentation and fight cold tumors like PDAC and GBM.
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Haiying Zhang is an Assistant Professor of Cell and Developmental Biology in Pediatrics at Weill Cornell Medical College, part of Cornell University, with an appointment beginning in 2016. Her research centers on extracellular vesicles and particles, including their roles in cancer metastasis, pre-metastatic niches, liver metabolic dysfunction, and immune responses. Key publications include "Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers" in Cell (2020), "Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation" in Nature Cell Biology (2018), "Tumour exosome integrins determine organotropic metastasis" in Nature (2015), "Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential" (2024), and "Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2" in Cell (2025). Additional works cover topics such as activated T cell extracellular vesicle DNA transfer, FGF13, and optimization of methods for plasma-derived extracellular vesicles. She has received funding from the Sohn Foundation for pediatric cancer research and the Daedalus Fund. Zhang is affiliated with the Lyden laboratory and contributes to studies on tumor-derived exomeres and biomarkers for cancer detection.
Her work has advanced understanding of extracellular vesicle and particle functions in cancer progression and systemic effects, with high citation impacts on publications addressing pre-metastatic niches and organ-specific metastasis. Professional appointments and research activities are documented through Weill Cornell Medicine sources and academic profiles.
Professional Email: nullWeill Cornell researchers discover how T cells secrete DNA-laden extracellular vesicles to enhance antigen presentation and fight cold tumors like PDAC and GBM.