Rate My Professor Hajime Kurosaki

Hajime Kurosaki serves as Lecturer in the Division of Genomic Medicine, Department of Genomic Medicine and Regenerative Therapeutics, School of Medicine at Tottori University Faculty of Medicine. His research centers on hematology and obstetrics and gynecology-related fields, with a focus on hemophilia, iPS cells, gene therapy, gene modification, oncolytic virus therapy, artificial chromosome vectors, and regenerative medicine. He has led multiple Grant-in-Aid for Scientific Research projects as principal investigator, including work on the development of oncolytic vaccinia virus with enhanced remote infection capability for ovarian cancer (2025–2027 and 2020–2022), development of cell replacement therapy for hemophilia using a novel artificial chromosome vector (2016–2019), correction models of hemophilia A mice using reprogramming factors and factor VIII gene with artificial chromosomes (2014–2016 and 2012–2013), and earlier projects on human artificial chromosomes for hemophilia therapy and factor VIII expression (2008–2011).

Kurosaki has contributed to publications including the 2009 book chapter on stem cell research advances regarding human artificial chromosome introduction into stem cells for medical and pharmaceutical applications, the 2015 paper “Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome” in BMC Biotechnology, the 2013 paper “An induced pluripotent stem cell-mediated and integration-free factor VIII expression system” in Biochemical and Biophysical Research Communications, the 2011 paper “Integration-free and stable expression of FVIII using a human artificial chromosome” in Journal of Human Genetics, and presentations on preclinical studies of tumor-targeted and armed oncolytic vaccinia virus for systemic cancer virotherapy at meetings such as the American Society of Gene and Cell Therapy and the Japan Society of Gene Therapy. His work involves collaborations on topics including fusogenic oncolytic vaccinia virus and cell-cell fusion approaches in genomic medicine.

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