Rate Professor Jacqueline Matthews

Professional Summary: Professor Jacqueline Matthews

Professor Jacqueline Matthews is a distinguished academic at the University of Sydney, Australia, with a notable career in the field of biochemistry and molecular biology. Her research and contributions have significantly advanced the understanding of protein interactions and their implications for disease mechanisms, particularly in cancer and developmental disorders.

Academic Background and Degrees

Professor Matthews holds a Ph.D. in Biochemistry from the University of Sydney, where she developed a strong foundation in molecular biology. Her academic training has equipped her with expertise in structural biology and protein chemistry, which are central to her research career.

Research Specializations and Academic Interests

Her primary research interests lie in the study of protein-protein interactions, transcriptional regulation, and the structural biology of disease-related proteins. Professor Matthews focuses on understanding the molecular basis of diseases such as leukemia and other cancers, using advanced techniques like NMR spectroscopy and X-ray crystallography to uncover novel therapeutic targets.

Career History and Appointments

• Professor of Molecular Biology, University of Sydney, School of Life and Environmental Sciences (current)
• Associate Professor, University of Sydney (prior appointment)
• Postdoctoral Research Fellow, University of Sydney and international institutions (early career)

Major Awards, Fellowships, and Honors

• Australian Research Council (ARC) Future Fellowship, recognizing her contributions to molecular biology
• Recipient of multiple ARC Discovery Project Grants for innovative research in protein interactions

Key Publications

Professor Matthews has authored numerous high-impact publications in peer-reviewed journals. Below is a selection of her notable works:

• 'Structural basis for the recognition of ldb1 by the N-terminal domain of the LIM homeodomain protein Lhx2' - Proceedings of the National Academy of Sciences (2002)
• 'The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the LIM domains of LIM-homeodomain proteins' - Molecular and Cellular Biology (2000)
• Multiple publications on LIM domain proteins and their role in transcriptional regulation in journals such as Nature Structural & Molecular Biology and Journal of Biological Chemistry (various years)

Influence and Impact on Academic Field

Professor Matthews has made significant contributions to the field of structural biology by elucidating the mechanisms of protein interactions involved in gene regulation and disease. Her work on LIM domain proteins has provided critical insights into developmental biology and cancer research, influencing therapeutic design and molecular biology studies worldwide. Her research is widely cited, and she collaborates with leading scientists globally to address complex biological challenges.

Public Lectures, Committees, and Editorial Contributions

• Regular speaker at international conferences on structural biology and molecular mechanisms of disease
• Member of grant review panels for the Australian Research Council (ARC)
• Contributor to editorial boards and peer review for leading journals in biochemistry and molecular biology