Rate My Professor Jeffrey Nanson

Nanson's research specializes in structural biology, utilizing protein crystallography and cryo-electron microscopy to uncover mechanisms of innate immune signaling. Key contributions include insights into the enzymatic activity of human SARM1 and plant TIR domain proteins, SARM1 activation driving axon degeneration and neuronal cell death, and cyclic signaling molecule production by bacterial NADases. His work has advanced understanding of Toll-like receptor adaptors like MyD88 and SCIMP, as well as TIR domain signaling in immunity and cell death pathways. Representative publications include 'NAD+ cleavage activity by animal and plant TIR domains in cell death pathways' (Science, 2019), 'SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration' (Neuron, 2021), 'Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling' (Science, 2022), 'Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules' (Molecular Cell, 2022), and 'Structural evolution of TIR-domain signalosomes' (Frontiers in Immunology, 2021). With over 1,600 citations on Google Scholar, Nanson's findings have significantly impacted the field of molecular immunology.