Rate My Professor Jennifer Cash

Cash's research specializes in the structure and function of RhoGEF signaling scaffolds, with a focus on the P-Rex subfamily and other Dbl RhoGEF family members. Her studies employ cryo-electron microscopy, X-ray crystallography, and biochemical methods to analyze protein domains such as the Pleckstrin Homology Domain of P-Rex2 and the catalytic core of P-Rex1, and their regulation by phosphoinositides like PIP3 (PtdIns(3,4,5)P3). Notable contributions include the development of small-molecule screening methods for inhibitors of cellular responses to myostatin and activin A (Cash et al., Journal of Biomolecular Screening, 2013), structural and biochemical characterization of P-Rex1's catalytic core (Cash et al., Structure, 2016), the Pleckstrin Homology Domain of P-Rex2 (Cash et al., Journal of Structural Biology: X, 2019), cryo-EM structure of the P-Rex1–Gβγ signaling scaffold (Cash et al., Science Advances, 2019), and discovery of small molecules targeting the P-Rex1 PIP3-binding site to inhibit functions in human neutrophils (Cash et al., Molecular Pharmacology, 2020). She is committed to advancing structural biology techniques and their application to signaling regulation.