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José Xavier-Neto earned his medical degree from the Universidade Federal do Ceará in 1989 and his doctorate in Ciências with a focus on Fisiologia Humana from the Universidade de São Paulo in 1993. He completed postdoctoral training in molecular biology at USP in 1995 and in developmental biology at Harvard University from 1997 to 1999, followed by training in genome modification techniques at Cold Spring Harbor Laboratory in 1999.
He served as a physician-researcher at the Instituto do Coração (InCor) and the Universidade de São Paulo, and as coordinator of the Transgenic Unit at the Hospital das Clínicas of the Faculdade de Medicina da Universidade de São Paulo. At the Laboratório Nacional de Biociências (LNBio) of the Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), he held the position of Level 6 researcher, where he established and led the Genome Modification Laboratory. His research centers on the biology and evolution of cardiac development, including the morphogenesis of cardiac chambers and coronary circulation, the evolutionary origins of cardiac chambers, congenital heart disease, and retinoic acid signaling. He led an international multidisciplinary team that described the first fossilized heart and developed an experimental model for Zika virus-induced developmental neuropathology. Xavier-Neto was elected and re-elected president of the Latin American Society for Developmental Biology (LASDB) in 2010 and 2012. He later served as visiting professor in the Department of Morphology at the Faculdade de Medicina da Universidade Federal do Ceará from 2019 to 2021 and as Chief Health Scientist of the State of Ceará from 2019 to 2023, during which he established the Centro de Inteligência em Saúde do Estado do Ceará (CISEC) and the Centro Multidisciplinar de Análises de Imagens Médicas e Biológicas (CMAI). In 2022, he received the Medalha Paulo Marcelo Martins Rodrigues from the State of Ceará for his contributions during the COVID-19 pandemic. He has also developed an innovative method for assessing the quality of public health care.
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