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Dr Jyoti Nangalia is a Group Leader in the Somatic Genomics Programme at the Wellcome Sanger Institute. Her research examines somatic mutation patterns, methylation changes and clonal selection across the human lifespan, with a focus on how these processes contribute to ageing and cancer development. Earlier work identified CALR mutations in the majority of patients with JAK2-unmutated myeloproliferative neoplasms, leading to routine clinical testing now incorporated into international WHO guidelines. She integrates genomic data with clinical parameters to develop personalised prognostic tools for blood cancers.
Dr Nangalia studied medicine at the University of Cambridge, St John’s College, where she earned a first-class BA and subsequently an MB BChir. She trained as a haematologist and completed a PhD at the University of Cambridge and the Wellcome Sanger Institute. She holds appointments as a Cancer Research UK Advanced Clinician Scientist Fellow, Group Leader at the Wellcome-MRC Cambridge Stem Cell Institute, and Honorary Consultant Haematologist at Cambridge University Hospitals NHS Foundation Trust, where she treats patients with chronic myeloid malignancies. She has been elected a Fellow of the Royal College of Physicians and a Fellow of the Academy of Medical Sciences. Her team contributes to national guidelines and leads molecular analysis for clinical trials in myeloproliferative neoplasms.
Explore the groundbreaking Cancer Discovery study from Wellcome Sanger Institute tracking blood cancer evolution over 25 years, identifying genetic predictors for progression in UK patients.
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