Rate My Professor Konstantin Roeder

Dr Konstantin Roeder is a Lecturer in Molecular Biochemistry at King’s College London, based in the Randall Centre for Cell & Molecular Biophysics within the School of Basic & Medical Biosciences. His research focuses on the structural diversity and dynamic configurations of biomolecules such as proteins and RNAs. Many of these molecules can adopt multiple stable structures, and the interplay between these configurations determines their functional roles. Computer-based methods, including explicit energy landscape explorations combined with other computational approaches, enable detailed characterisation of thermodynamic, kinetic and structural properties that may be inaccessible to experimental techniques alone.

Key research areas include the study of non-coding RNAs (ncRNAs) and their involvement in regulatory processes such as translation and transcription, as well as their roles in viral mechanisms and disease. A central challenge addressed is the structural polymorphism exhibited by these molecules. Additional work examines how perturbations, including mutations, chemical modifications and environmental factors such as forces or pH, influence the balance of configurations in proteins and RNAs, potentially leading to gains or losses of function. This computational framework provides new avenues for interpreting experimental data and understanding biomolecular behaviour in complex biological contexts.