Lin He is the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research and Professor of Cell Biology, Development and Physiology in the Department of Molecular and Cell Biology at the University of California, Berkeley, where she has been a faculty member since 2008. She earned her B.S. in Biology from Tsinghua University, her Ph.D. from Stanford University under the mentorship of Gregory S. Barsh, and completed postdoctoral training at Cold Spring Harbor Laboratory with Greg Hannon. He is also an affiliate in the Division of Immunology and Pathogenesis and a Chan Zuckerberg Biohub Investigator. Her career includes recognition as a Howard Hughes Medical Institute Faculty Scholar.

He's research centers on the biological functions and molecular regulation of non-coding genome elements, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and transposable elements, in mammalian development and disease. Employing interdisciplinary approaches including mouse genetics, genomics, cell biology, and molecular biology, her lab elucidates crosstalk among non-coding RNAs, transposons, and protein-coding genes that govern processes like stem cell pluripotency, ciliogenesis, preimplantation embryogenesis, reproductive aging, and cancer progression and metastasis. Key innovations include the development of CRISPR Ribonucleoprotein Electroporation of Zygotes (CRISPR-EZ), a highly efficient, economical method for genome editing in mouse zygotes achieving 100% efficiency with improved embryo viability. Her highly influential publications encompass 'MicroRNAs: small RNAs with a big role in gene regulation' (Nature Reviews Genetics, 2004), 'A microRNA polycistron as a potential human oncogene' (Nature, 2005), 'A microRNA component of the p53 tumour suppressor network' (Nature, 2007), 'miR-19 is a key oncogenic component of mir-17-92' (Genes & Development, 2009), and 'miR-34/449 miRNAs are required for motile ciliogenesis by repressing Cp110' (Nature, 2014). He has received the MacArthur Fellowship in 2009 and the Carcinogenesis Young Investigator Award in 2014. With over 26,000 citations, her work has profoundly shaped understanding of the non-coding genome's complexity and its roles in development and pathology.

Professional Email: lhe@berkeley.edu