Mark Douglas

Professor Mark Douglas is Professor of Infectious Diseases and Hepatic Medicine at the University of Sydney's Faculty of Medicine and Health, affiliated with the Westmead Clinical School. He earned his BSc(Med)(Hons), MBBS(Hons), and PhD in molecular virology from the University of Sydney, and is a Fellow of the Royal Australasian College of Physicians (FRACP). After completing his PhD, he served as an NHMRC CJ Martin Postdoctoral Research Fellow at the MRC-University of Glasgow Centre for Virus Research from 2005 to 2007. Since 2007, he has held positions at the University of Sydney, progressing to Professor and Research Academic Director - Clinical Science at Westmead Clinical School. He is also Senior Staff Specialist in Infectious Diseases at Westmead Hospital (NSW Local Health District) and Head of the Viral Hepatitis Pathogenesis group at the Storr Liver Centre, Westmead Institute for Medical Research.

His research interests center on viral hepatitis, including hepatitis B, C, and D viruses, focusing on molecular pathogenesis, virus-host interactions, replication, antiviral drug resistance, liver fibrosis, steatosis, inflammation, oncogenesis, innate immunity, and mitochondrial dysfunction. Additional areas include SARS-CoV-2 (COVID-19). He conducts clinical research and manages patients in liver clinics for hepatitis B and C, as well as HIV and other infectious diseases at Westmead Hospital. Notable publications include "Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner" (2008, 298 citations), "Molecular mechanisms of insulin resistance in chronic hepatitis C" (2009, 116 citations), "The paradox of HBV evolution as revealed from a 16th century mummy" (2018, 117 citations), "Australia on track to achieve WHO HCV elimination targets following rapid initial DAA treatment uptake: a modelling study" (2019, 84 citations), and "Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer" (2023). With over 3,700 citations on ResearchGate, his work has significantly impacted the field of viral hepatitis research. He contributes to editorial roles as Associate Editor for Viruses and is involved with the Australasian Society for Infectious Diseases Viral Hepatitis Special Interest Group.

Professional Email: mark.douglas@sydney.edu.au