Paul Gooley

Professor Paul Gooley is a Professor in Biochemistry and Molecular Biology at the University of Melbourne, affiliated with the School of Biomedical Sciences, Department of Biochemistry and Pharmacology, and the Bio21 Molecular Science and Biotechnology Institute. He holds BSc and PhD degrees and heads the Gooley laboratory specializing in receptor structural biology. Gooley's research employs solution nuclear magnetic resonance (NMR) spectroscopy to determine protein structures, dynamics, and interactions, with a focus on G protein-coupled receptors (GPCRs), peptide receptors, viral proteins, and disease-associated biomolecules. His laboratory investigates ligand binding, allosteric mechanisms, conformational dynamics, and protein phase separation, contributing to insights into drug development and disease mechanisms such as those in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and rabies virus infections.

Gooley has an extensive publication record exceeding 200 papers, with key contributions including 'Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes' (2008), 'Macromolecular NMR spectroscopy for the non-spectroscopist' (2011), 'Optimisation of NMR dynamic models I. Minimisation algorithms and their performance within the model-free and Brownian rotational diffusion spaces' (2008), 'Increased d-lactic acid intestinal bacteria in patients with chronic fatigue syndrome' (2009), 'The NMR structure of the inhibited catalytic domain of human stromelysin-1' (1994), 'SnRK1 from Arabidopsis thaliana is an atypical AMPK' (2015), and 'Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients' (2015). Recent works encompass 'Exploring a genetic basis for the metabolic perturbations in ME/CFS using UK Biobank' (2025), 'Conformational dynamics, RNA binding, and phase separation regulate the multifunctionality of rabies virus P protein' (2025), and 'Machine learning and multi-omics in precision medicine for ME/CFS' (2025). He coordinates courses such as Cell Signalling and Neurochemistry (BCMB30004) and manages facilities like the Isothermal Titration Calorimeter at Bio21. His scholarship, cited over 6,000 times, advances NMR methodologies and biomolecular understanding in health and disease contexts.

Professional Email: prg@unimelb.edu.au