Rate My Professor Shimin Zhao

Shimin Zhao is a professor in the School of Life Sciences at Fudan University and deputy dean of the Institute of Metabolism and Integrative Biology. He studied in the Chemistry Department of Beijing Normal University from 1984 to 1988, conducted research at the Chinese Academy of Medical Sciences from 1988 to 1995, and obtained a doctorate degree in biochemistry from Purdue University in 2000. Following his PhD, he worked at Procter & Gamble and other companies from 2000 to 2005 before joining Fudan University in 2006 as an associate researcher, professor, and doctoral supervisor. Currently, he serves as senior principal investigator at the Institutes of Biomedical Sciences, principal investigator at the State Key Laboratory of Genetic Engineering, and chief scientist of the National Major Scientific Research Plan for Protein Research.

Professor Zhao's research centers on metabolic regulation mechanisms, the relationship between metabolic disorders and human diseases, protein post-translational modifications, and proteomics. His work investigates the pathogenesis and intervention methods for human diseases arising from metabolic enzyme acetylation modification disorders and tumors caused by metabolic intermediate dysregulation. Key publications include 'Regulation of Cellular Metabolism by Protein Lysine Acetylation' (Science, 2010), 'Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α' (Science, 2009), 'Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases' (Cancer Cell, 2011), 'Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux' (Science, 2010), 'Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis that Promotes Clear Cell Renal Cell Carcinoma Growth' (Cancer Research, 2020), and 'Hypoxia Induces Mitochondrial Protein Lactylation to Limit Tumorigenesis' (Cell Research, 2024). He has received the 2018 Leading Talent of National High-Level Talent Special Support Program Ten Thousand People Plan, 2017 Second Prize of Chinese Medical Science and Technology Award, 2016 Head of the Innovation Team in Key Areas of the Ministry of Science and Technology, 2013 First Prize of Natural Science of the Ministry of Education (first accomplisher), 2010 Top Ten Scientific and Technological Progress of Chinese Universities, and 2010 Top Ten Progress of Science in China.