Rate My Professor Zhenheng Guo

Dr. Guo's contributions include pivotal publications such as 'Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formation' (Journal of Biological Chemistry, 2012), 'Role of Calcium-independent Phospholipase A2β in High Glucose-induced Activation of RhoA, Rho-kinase, and CPI-17 in Cultured Vascular Smooth Muscle Cells and Vascular Smooth Muscle Hypercontractility in Diabetic Animals' (Journal of Biological Chemistry, 2010), 'Group VIA phospholipase A2 (iPLA2β) participates in angiotensin II-induced transcriptional upregulation of RGS2 in vascular smooth muscle cells' (Journal of Biological Chemistry, 2007), and 'Ca²⁺-independent Phospholipase A2 Is Required for Agonist-induced Ca²⁺ Sensitization of Contraction in Vascular Smooth Muscle' (Journal of Biological Chemistry, 2003). Current projects examine the roles of smooth muscle iPLA2β in angiotensin II-induced RGS2 regulation, diabetes-associated vascular hypercontractility, vascular inflammation, mineralocorticoid receptor in salt-induced aneurysms, and BMAL1 in blood pressure circadian rhythm. He received the Alan T. Hirsch Mid-Career Award in Vascular Medicine in 2016. Recent studies address circadian variations in vasoconstriction, time-restricted eating effects on hypertension, and sex-specific differences in aortic aneurysms.