New Risk Factors for Dementia Identified: Lancet Study from Lund University Reveals Two New Dementia Risk Factors That Could Prevent Nearly Half of Ca

🧠 Unveiling the Latest Breakthrough from Lund University

In a compelling advancement in dementia research, scientists at Lund University in Sweden have pinpointed specific mechanisms through which everyday lifestyle choices influence brain health, potentially paving the way to prevent nearly half of all dementia cases. 74 73 This prospective cohort study, published in early 2026 in The Journal of Prevention of Alzheimer’s Disease, tracked nearly 500 cognitively healthy individuals averaging 65 years old over four years. Using advanced imaging like MRI and PET scans alongside cerebrospinal fluid analysis, the researchers linked modifiable risk factors to damaging changes in the brain associated with Alzheimer's disease and vascular dementia—the two most prevalent forms.

Senior author Sebastian Palmqvist, a neurology expert at Lund University and Skåne University Hospital, emphasized, “Much of the research available on the risk factors that we ourselves can influence does not take into account the different causes of dementia.” 74 Lead investigator Isabelle Glans added that targeting these factors could significantly delay symptom onset, even in cases involving mixed brain pathologies.

Understanding Dementia: The Basics Explained

Dementia is an umbrella term for a decline in cognitive function severe enough to interfere with daily life, affecting memory, thinking, and behavior. Alzheimer's disease accounts for 60-70% of cases, characterized by the buildup of amyloid beta plaques and tau protein tangles that disrupt neuron communication. Vascular dementia, comprising about 20%, stems from reduced blood flow to the brain due to damaged vessels, often showing as white matter hyperintensities (WMH)—bright spots on MRI scans indicating small vessel disease and tissue damage.

Many individuals develop mixed dementia, where both processes overlap, complicating diagnosis and treatment. Non-modifiable risks like age, genetics (e.g., APOE ε4 allele), and sex play roles, but approximately 45% of cases worldwide are tied to modifiable factors, echoing findings from the 2024 Lancet Commission report. 62

📊 The Two Newly Identified Risk Factors

The Lund study highlights two novel associations deserving further exploration: diabetes and low body mass index (BMI).

• Diabetes: This chronic condition, where blood sugar levels remain high due to insulin issues, was linked to faster accumulation of amyloid beta proteins—a hallmark of Alzheimer's. In the cohort, participants with diabetes showed a β coefficient of 0.02 (95% CI: 0.00–0.04) for amyloid beta increase, suggesting metabolic inflammation or vascular complications accelerate plaque formation.
• Low BMI: Surprisingly, lower body weight (BMI under 25) correlated with quicker tau protein buildup (β=-0.01, 95% CI: -0.02–-0.01), potentially indicating malnutrition, reduced cognitive reserve, or altered energy metabolism affecting neuron stability.

Isabelle Glans noted, “Diabetes was associated with increased accumulation of amyloid β, while people with lower BMI had faster accumulation of tau. However, these findings need to be investigated further and validated in future studies.” 74 These insights expand our understanding beyond traditional risks.

🔬 Confirmed Links to Vascular Brain Damage

The research robustly confirms several modifiable factors driving white matter hyperintensities, a precursor to vascular dementia:

• High blood pressure (hypertension): β=0.02 (0.01–0.02)
• High blood lipids (hyperlipidemia, akin to high LDL cholesterol): β=0.03 (0.01–0.05)
• Ischemic heart disease: β=0.06 (0.03–0.09)
• Smoking: β=0.02 (0.00–0.03)
• Lower education: β=-0.01 (-0.02–-0.01)

These accelerate vessel damage, impairing oxygen delivery and fostering infarcts. Palmqvist explained, “We saw that most modifiable risk factors... were linked to damage to the brain's blood vessels and a faster accumulation of so-called white matter changes.” 74

APOE ε4 carriers showed heightened vulnerability across markers, underscoring genetic-lifestyle interplay.

🌍 Broader Context: Aligning with the Lancet Commission

This Lund research builds on the influential 2024 Lancet Commission, which updated its list to 14 modifiable risk factors accounting for 45.4% of global dementia (50.9% in low/middle-income countries). 62 The Commission added untreated vision loss (2%) and high midlife LDL cholesterol (7%), complementing Lund's high lipids finding. Full list includes:

• Less education (childhood)
• Hearing loss, head injury (early-life)
• Hypertension, obesity, depression, physical inactivity, diabetes, smoking, high cholesterol (midlife)
• Social isolation, air pollution, vision loss (late-life)

Read the Alzheimer's International summary for intervention strategies.

💡 Practical Prevention Strategies

Armed with this knowledge, proactive steps can safeguard brain health:

1. Monitor and manage vascular risks: Keep blood pressure below 130/80 mmHg via diet (DASH: fruits, veggies, low sodium), exercise (150 min/week moderate), and meds if needed.
2. Control cholesterol and diabetes: Statins for high LDL; balanced carbs, fiber-rich foods, regular A1C checks.
3. Maintain healthy weight: Aim BMI 20-25; avoid extremes through portion control, strength training.
4. Quit smoking and limit alcohol: Cessation programs; <14 units/week.
5. Boost cognitive reserve: Lifelong learning, social engagement, hearing/vision aids.

Glans advises, “Focusing on vascular and metabolic risk factors can still help reduce the combined effects of several brain changes.” Start small—daily walks yield big gains. 74

🎓 Opportunities in Dementia Research Academia

Such studies highlight booming demand for neuroscience experts. Lund's work exemplifies interdisciplinary efforts in neurology, radiology, and epidemiology. Aspiring researchers can explore research jobs or professor positions in higher education, contributing to trials on biomarkers or interventions. Check higher ed jobs for roles at institutions driving these discoveries. Salaries for professors in this field often exceed industry averages—see professor salaries data.

Dive into the full Lund University article or access the peer-reviewed paper.

Photo by Sofia Puchkova on Unsplash

Forward Outlook: A Preventable Future

The synergy of Lund's granular brain-pathway insights and Lancet's global framework offers hope: nearly half of dementia may be avertable through lifestyle and policy. As research accelerates, academic institutions worldwide seek talent to translate findings into public health wins. Share your thoughts in the comments, rate neuroscience courses via Rate My Professor, or browse higher ed jobs and university jobs to join the fight. Explore higher ed career advice for tips on thriving in research roles. Prioritize brain health today—your future self will thank you.