Job Title: [50006078-RSE3A] Senior Scientist I, Food & Nutrition

Requisition ID: 1742

Posting Start Date: 04/05/2026

Long Description

Key Responsibilities

• Lead development and optimisation of GPCR functional assays, including reporter-based systems (e.g., luciferase, cAMP, calcium, β-arrestin readouts) suitable for medium- to high-throughput screening.
• Develop new reporter systems for additional functional or phenotypic endpoints beyond GPCR signalling.
• Design, generate, and validate stable or transient mammalian reporter cell lines, including construct design, molecular cloning, and cell line engineering.
• Collaborate with cross-functional teams (e.g., chemistry, computational biology, screening teams) to support compound evaluation and mechanistic studies.
• Analyse and interpret experimental data, including dose-response relationships, assay performance metrics, and screening outputs.
• Prepare scientific reports, presentations, and publications, and maintain rigorous documentation of experimental workflows.
• Supervise and train junior staff members, students, and interns.

Requirements

• PhD in Molecular Biology, Cell Biology, Synthetic Biology, Biochemistry, Pharmacology, or a related discipline.
• Strong hands-on experience in mammalian cell culture and cell line engineering, including transfection, selection, and maintenance of stable lines.
• Proven experience in designing and implementing reporter assays in mammalian systems (e.g., luciferase, fluorescent, or biosensor-based systems).
• Strong molecular biology and cloning skills, including construct design, vector systems, and DNA assembly techniques.
• Experience with GPCR biology and signalling pathways and/or assay formats used in GPCR screening is highly preferred.
• Demonstrated ability to independently design, execute, and troubleshoot experiments.
• Familiarity with assay development for screening applications, including optimisation of robustness and reproducibility
• Excellent communication skills and ability to work in a multidisciplinary team environment.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.