Advanced Non-Invasive Strategies: Cell-Penetrating Peptides as Smart Carriers for Theranostic Innovations
About the Project
The brain contains trillions of glial cells that communicate with each other, respond to infections, and support learning and memory. Cell-penetrating peptides (CPPs) are highly promising for delivering proteins or peptides into glial cells. Focused ultrasound (FUS) combined with microbubbles offers a non-invasive method to deliver agents across the BBB.
Project Overview
- Objective: Engineer and deliver a novel CPP that selectively targets glial cells in vivo.
- Innovation: Incorporate a non-proteinogenic amino acid into the peptide structure to enhance stability.
- Theranostic Capabilities: Tag the CPP with a fluorophore and encapsulate it with gold nanoparticles.
Key Methodologies
- Peptide Synthesis
- Delivery Techniques using focused ultrasound and gold nanoparticle encapsulation
- Ex Vivo Analysis
- Scoping review and focus groups
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