Job Information
Organisation/Company: Malopolska Centre of Biotechnology
Research Field: Biological sciences » Other; Chemistry
Researcher Profile: Recognised Researcher (R2)
Positions: Postdoc Positions
Application Deadline: 31 Oct 2026 - 23:59 (Europe/Warsaw)
Country: Poland
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 40
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description
Jagiellonian University in Kraków promotes cooperation and cares for a good atmosphere based on mutual trust. It implements the strategy resulting from The Human Resources Strategy for Researchers, creating stable conditions for employment as well as the development of academic career, which resulted in the award of the HR Excellence in Research by the European Commission
INFORMATION ON SELECTION PROCEDURE
Date of selection procedure announcement Krakow, 01.10.2026
Selection procedure information number given by the Centre for Human Resources 1227.1101.247.2026
Dean (F/M) of the Faculty of / Director (F/M) of a non-faculty, inter-faculty or common unit Director of the Malopolska Centre of Biotechnology
dr Serghei Mangul, prof. UJ
Address Malopolska Centre of Biotechnology Gronostajowa 7A, 30-387 Cracow
RECTOR
of the Jagiellonian University
announces a selection procedure for the position of an
ASSISTANT PROFESSOR (F/M)
Group of employees (F/M) Research staff
JU organisational unit (place of work performance) Polyamine Networks Research Group
Małopolska Centre of Biotechnology
Field of science Science and life sciences
Discipline Biological sciences or Chemical sciences
Scope Structural biology, biochemistry, medicinal chemistry, molecular biology, biophysics, synthetic chemistry or related
Number of posts 1
Type of employment Employment contract
Working time Full time
Planned duration of employment 12 months
Expected date of employment commencement First quarter 2027
Remuneration
• basic remuneration in the range of 10 523‒12 839 PLN gross;
• seniority allowance depending on length of service (3‒20%);
• jubilee awards for long-term service ‒ in accordance with the Regulation for remuneration of employees of the Jagiellonian University;
• possible task-based and periodic allowances, as well as discretionary awards, upon meeting the conditions set out in the Regulation for remuneration of employees of the Jagiellonian University;
• additional annual remuneration, the so-called "thirteenth salary" ‒ after meeting the conditions specified in the relevant regulation. Benefits ‒ Institutional Social Benefits Fund (depending on the income per family member, in accordance with the Regulations for Granting Benefits from the Company Social Benefits Fund of the Jagiellonian University):
• co-financing of summer holidays (PLN 1 050–1 550 gross) and winter holidays (PLN 700–900 gross);
• co-financing for children for organised holidays (PLN 900–1 400 gross), or co-financing of individually purchased summer camps, sports camps, winter camps, medical holidays or rehabilitation stays (50–90%, with the maximum amount eligible for co-financing being PLN 2 500 gross) per child;
• cash equivalent for a special occasional package of sweets in the amount of PLN 100–300 gross per child;
• co-financing of childcare in nurseries, kindergartens and other forms of preschool education, as well as care provided by a daily guardian or nanny (PLN 250–400 gross).
Requirements
The selection procedure is open for all individuals, who meet the requirements set out in Articles 113 and 116.2.3) of the Act of 20 July 2018 – Law on Higher Education and Science, and who meet the following eligibility criteria according to §165 of the Statute of the Jagiellonian University:
• holding at least a doctoral degree;
• having relevant scientific achievements;
• taking active part in scientific life.
Additional requirements necessary for employment (indicated in order of priority)
Ideal Candidates (F/M):
• have relevant scientific background in cell biology, molecular biology, biochemistry and/or related fields,
• have at least one original scientific publication, in which they are the lead author,
• take an active part in scientific life manifested in particular in presentations at conferences and symposia,
• meet the NCN requirements for persons employed in research projects [https://www.ncn.gov.pl/sites/default/files/pliki/uchwaly-rady/2022/uchw…],
• in addition, the Candidates (F/M) are expected to have prior knowledge and experience in at least one of the following methods: experience in research in the field of structural biology (crystallography or cryo-EM), biochemistry, biophysics, studies of protein–protein interactions, drug design, screening techniques, molecular biology, biophysics, and related areas.
The ideal Candidate (F/M) will possess:
• knowledge of techniques for purification of recombinant and native proteins,
• knowledge of molecular biology methods, e.g. cloning, design of expression constructs, Western blot, RT-PCR,
• knowledge of prokaryotic and eukaryotic protein expression systems,
• experience in studying protein activity using various enzymatic assays,
• experience in macromolecular structure analysis,
• experience in synchrotron measurements or cryo-EM,
• experience with SPR, HPLC, MST methods,
• command of English at a communicative level, enabling daily work in an international scientific environment, presenting results, and preparing scientific publications,
• knowledge of basic MS Office programs and optionally Linux operating system environment and software such as CCP4, Phenix, Relion, CryoSPARC, PanDDa, PyMOL, GraphPad/Origin.
Project Title: NCN OPUS 24, “Targeted inhibition of hypusination pathway”.
PSP: K/NCN/000211
Project description
Hypusination is a modification described only for one protein: the eukaryotic translational factor eIF5A, and spermidine is used as a substrate in this process. In the first step of hypusination, the enzyme deoxyhypusine synthase (DHS) attaches the 4-aminobutyl moiety of spermidine to the lysine residue present in eIF5A, resulting in the formation of a non-standard amino acid residue: deoxyhypusine. The deoxyhypusine is then modified to hypusine by deoxyhypsuine hydroxylase (DOHH). eIF5A is involved in the protein translation process, and hypusinated lysine is essential for its activity. eIF5A is also involved in the development of certain diseases such as diabetes, certain types of cancer, and malaria. Furthermore, hypusinated eIF5A promotes cell proliferation. Much attention is currently being paid to the molecular mechanism of selective control of protein translation by hypusinated eIF5A. Hypusinated eIF5A is indispensable for tumor growth and is closely related to the aggressiveness of cancers. Moreover, the expression of the second eIF5A-2 variant is a hallmark of many cancers. Furthermore, mutations in proteins involved in the hypusination pathway are the cause of neurological disorders. To date, we are simply lacking molecular compounds that enable us to specifically modulate the hypusination pathway, and the structure ‒ activity relationship of the currently used inhibitors is vaguely defined, as there are major concerns about the specificity of these molecules. Hence, the ultimate goal of the project is to obtain lead compounds selectively modulating the hypusination pathway that can be further optimized as pro-drugs or tool compounds to be used in diagnostics and clinical treatment. In detail, we plan to transform the small molecules obtained in our previous research into novel lead compounds that can serve as pro-drug molecules. These molecules will be thoroughly tested in various activity screens, and we will obtain crystal structures of DHS in complexes with developed compounds. Furthermore, using high-throughput crystallographic screening, we will discover new small-molecule DOHH binders, which will pave the way for the synthesis of novel inhibitors and thus, together with DHS-interacting compounds, complement the landscape of hypusination pathway modulators. Last but not least, we plan a multifaceted strategy in which not only small compounds but also nucleic acid-based aptamers will be tested as possible hypusination modulators.
Scope of duties
According to the Work Regulations of the Jagiellonian University Annex 1 to the Work Regulations of the Jagiellonian University – Model scopes of responsibilities and duties of academic teachers (F/M)
The hired person will be responsible for independently coordinating tasks, making rational and logical decisions to solve problems, and introducing new techniques and tools. The best-selected Candidate (F/M) will be required to learn and optimize new methods in the fields of structural biology, biochemistry, biophysics, and medicinal chemistry. The work will include optimizing selected activity assays, conducting experiments based on activity tests, designing new inhibitors, preparing samples for structural studies, and preparing reports.
We offer
• stable employment based on an employment contract at the renowned university,
• cooperation with the interdisciplinary academic community represented by well-known scientists,
• scientific support as well as the possibility of qualifications improvement and professional development,
• access to research infrastructure,
• benefits in the form of i.a. Multisport card, sports activities, medical packages, group insurance,
• additional social benefits.
Required application documents
1. resume,
2. personal questionnaire filled in by the Candidate (F/M),
3. copy of the doctoral diploma or a diploma confirming the Candidate’s (F/M) habilitation degree, if applicable,
4. information on the Candidate’s (F/M) scientific, teaching and organisational achievements,
5. declaration of the Candidate (F/M), confirming that the Jagiellonian University will be their primary place of work, should they be selected in the selection procedure,
6. statement under Article 113 of the Law on Higher Education and Science,
7. statement on acknowledging and accepting the rules and regulations concerning intellectual property management and commercialisation in force at the Jagiellonian University,
8. list of publications (along with the respective publishing houses and the number of pages), if any,
9. recommendation from the Candidate's (F/M) previous supervisor (head of the department or academic supervisor) regarding the Candidate's (F/M) aptitude and qualifications for academic teaching and research work, including the results of student surveys and evaluations, if the Candidate (F/M) was subject to such evaluation.
Declaration forms (no. 5‒7) and personal questionnaire template (no. 2) can be obtained at:
https://cso.uj.edu.pl/en_GB/dokumkandyd
The course of selection procedure
The first stage of the selection procedure is the formal assessment of the submitted documents. Applications which meet all formal requirements are the subject of substantive assessment, during which an interview with the Candidate (F/M) may be conducted (directly or via electronic communication channels), upon settling the date of the interview with the Candidate (F/M). During the interview, the soft competencies indicated in the announcement will also be verified. The Candidate (F/M) has the right to appeal against the negative assessment by the selection board within 7 days from receiving the information about the results of the assessment. The selection procedure is conducted in accordance with The Policy of Open, Transparent and Merit-Based Recruitment Process at the Jagiellonian University.
Form of submission
by e-mail to the address: job.mcb@uj.edu.pl, title: 247.2026 assistant professor OPUS 24
Deadline for submission of applications 31.10.2026
Expected date of the selection procedure settlement 30.11.2026
Method of communicating of the results of the selection procedure by e-mail
Questions
For further information please contact by e-mail: job.mcb@uj.edu.pl
In the selection procedure, the Jagiellonian University follows the principles of the European Charter for Researchers and a Code of Conduct for the Recruitment of Researchers.
Jagiellonian University does not provide housing.
The selection procedure does not provide for any preferences or decisions that differentiate between Candidates (F/M) on the basis of gender; the evaluation process is conducted in accordance with the principles of equal treatment and gender neutrality.
Jagiellonian University has an internal procedure for reporting violations of the law and protecting persons making such reports (whistleblowers), in accordance with applicable regulations. Order of the Rector of Jagiellonian University on the Procedure for reporting violations of the law and taking follow-up action at Jagiellonian University.
On behalf of
the Rector of the Jagiellonian University
Director of the Malopolska Centre of Biotechnology
dr Serghei Mangul, prof. UJ
Where to apply
E-mail: job.mcb@uj.edu.pl
Requirements
Research Field: Biological sciences » Other
Education Level: PhD or equivalent
Skills/Qualifications
Requirements
The selection procedure is open for all individuals, who meet the requirements set out in Articles 113 and 116.2.3) of the Act of 20 July 2018 – Law on Higher Education and Science, and who meet the following eligibility criteria according to §165 of the Statute of the Jagiellonian University:
• holding at least a doctoral degree;
• having relevant scientific achievements;
• taking active part in scientific life.
Specific Requirements
Additional requirements necessary for employment (indicated in order of priority)
Ideal Candidates (F/M):
• have relevant scientific background in cell biology, molecular biology, biochemistry and/or related fields,
• have at least one original scientific publication, in which they are the lead author,
• take an active part in scientific life manifested in particular in presentations at conferences and symposia,
• meet the NCN requirements for persons employed in research projects [https://www.ncn.gov.pl/sites/default/files/pliki/uchwaly-rady/2022/uchw…],
• in addition, the Candidates (F/M) are expected to have prior knowledge and experience in at least one of the following methods: experience in research in the field of structural biology (crystallography or cryo-EM), biochemistry, biophysics, studies of protein–protein interactions, drug design, screening techniques, molecular biology, biophysics, and related areas.
The ideal Candidate (F/M) will possess:
• knowledge of techniques for purification of recombinant and native proteins,
• knowledge of molecular biology methods, e.g. cloning, design of expression constructs, Western blot, RT-PCR,
• knowledge of prokaryotic and eukaryotic protein expression systems,
• experience in studying protein activity using various enzymatic assays,
• experience in macromolecular structure analysis,
• experience in synchrotron measurements or cryo-EM,
• experience with SPR, HPLC, MST methods,
• command of English at a communicative level, enabling daily work in an international scientific environment, presenting results, and preparing scientific publications,
• knowledge of basic MS Office programs and optionally Linux operating system environment and software such as CCP4, Phenix, Relion, CryoSPARC, PanDDa, PyMOL, GraphPad/Origin.
Languages: ENGLISH
Level: Good
Additional Information
Benefits
We offer
• stable employment based on an employment contract at the renowned university,
• cooperation with the interdisciplinary academic community represented by well-known scientists,
• scientific support as well as the possibility of qualifications improvement and professional development,
• access to research infrastructure,
• benefits in the form of i.a. Multisport card, sports activities, medical packages, group insurance,
• additional social benefits.
Selection process
Required application documents
1. resume,
2. personal questionnaire filled in by the Candidate (F/M),
3. copy of the doctoral diploma or a diploma confirming the Candidate’s (F/M) habilitation degree, if applicable,
4. information on the Candidate’s (F/M) scientific, teaching and organisational achievements,
5. declaration of the Candidate (F/M), confirming that the Jagiellonian University will be their primary place of work, should they be selected in the selection procedure,
6. statement under Article 113 of the Law on Higher Education and Science,
7. statement on acknowledging and accepting the rules and regulations concerning intellectual property management and commercialisation in force at the Jagiellonian University,
8. list of publications (along with the respective publishing houses and the number of pages), if any,
9. recommendation from the Candidate's (F/M) previous supervisor (head of the department or academic supervisor) regarding the Candidate's (F/M) aptitude and qualifications for academic teaching and research work, including the results of student surveys and evaluations, if the Candidate (F/M) was subject to such evaluation.
Declaration forms (no. 5‒7) and personal questionnaire template (no. 2) can be obtained at:
https://cso.uj.edu.pl/en_GB/dokumkandyd
The course of selection procedure
The first stage of the selection procedure is the formal assessment of the submitted documents. Applications which meet all formal requirements are the subject of substantive assessment, during which an interview with the Candidate (F/M) may be conducted (directly or via electronic communication channels), upon settling the date of the interview with the Candidate (F/M). During the interview, the soft competencies indicated in the announcement will also be verified. The Candidate (F/M) has the right to appeal against the negative assessment by the selection board within 7 days from receiving the information about the results of the assessment. The selection procedure is conducted in accordance with The Policy of Open, Transparent and Merit-Based Recruitment Process at the Jagiellonian University.
Form of submission
by e-mail to the address: job.mcb@uj.edu.pl, title: 247.2026 assistant professor OPUS 24
Deadline for submission of applications 31.10.2026
Expected date of the selection procedure settlement 30.11.2026
Method of communicating of the results of the selection procedure by e-mail
Questions
For further information please contact by e-mail: job.mcb@uj.edu.pl
Additional comments
More information: https://praca.bip.uj.edu.pl/documents/145868730/161593059/1227.1101.247…
Work Location(s)
Number of offers available: 1
Company/Institute: Jagiellonian University
Country: Poland
Contact
State/Province: Malopolska
City: Cracow
Website: https://mcb.uj.edu.pl/en_GB/
Street: Gronostajowa 7a
Postal Code: 30-387