Avesicular nanoparticles (avNPs) are novel intercellular communication factors promoting prostate cancer.

About the Project

This is a Self-Funded/Sponsored PhD opportunity.

FUNDING REQUIRED:

• Full UK/EU or International Tuition Fees
• UK Living Expenses
• Bench Fees (£41,000 total)

Open to all students of any nationality without restrictions (UK/EU and International)

Description:

We're on the hunt for a passionate PhD student to explore the fascinating world of extracellular vesicles and avesicular nanoparticles (avNPs) in Prostate Cancer.

Why This Project?

Cells are not just static entities; they are dynamic factories producing extracellular vesicles that influence their surroundings. These tiny particles can modulate immune responses, alter tissue architecture, and even promote cancer growth and metastasis. Understanding and targeting these vesicles is a hot topic globally, with immense potential for drug delivery and disease markers.

Cells also produce avNPs such as exomeres and supermeres. These nano-aggregates of proteins and RNAs are a mystery, lacking lipid membranes and playing unclear roles in cancer. Our project aims to unravel these mysteries through comprehensive and rigorous analysis, focusing on their production by prostate cancer cells and their interactions within the complex cancer microenvironment.

What You'll will Do?

In this role, you'll dive into groundbreaking research on avesicular nanoparticles (avNPs) in prostate cancer. You'll employ advanced physical science metrology tools and molecular profiling techniques to characterize avNPs and observe how they change under cellular stress, such as hypoxia. Utilizing a variety of multicellular models, fluorescent imaging, and diverse cellular assays, you'll investigate how these nanoparticles target recipient cells, their responses, and the underlying mechanisms of their effects. Additionally, you'll explore the potential of avNPs as biomarkers in biofluids, providing crucial insights into disease status. This is a unique opportunity to make a significant impact in the fight against cancer.