Peking University

Chemical Biology: Small-Molecule Probes to Decode Biological Processes

Closes: Oct 17, 2026

About the Project

Projects in this direction will use small molecules and bioactive natural products to investigate fundamental biological questions across human, plant, animal and microbial systems. Individual projects may focus on disease mechanisms, plant immunity, insect behaviour, host–pathogen interactions or chemical communication between organisms.

Depending on the research question, you may combine chemical synthesis, activity-guided discovery, chemical proteomics, quantitative mass spectrometry, biophysical analysis, genetics, imaging and multi-omics to identify molecular targets and define the underlying mechanisms and regulatory networks.

Applicants from chemistry, biochemistry, molecular biology, plant science, pharmacology and related disciplines are welcome.

Competitive scholarships are available. Candidates must apply separately for scholarship support. Funding is not guaranteed and is awarded based on academic merit.

Principal Investigator: Professor Xiaoguang Lei

Email: xglei@pku.edu.cn

Telephone: +86-10-6276-0292

Laboratory webpage: https://www.chem.pku.edu.cn/leigroup/

Applications accepted all year round. Self-funded PhD students only.

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Chemical Biology: Small-Molecule Probes to Decode Biological Processes