brain and a comprehensive genetic toolkit for the selective manipulation of each uniquely identified neuron type.
Possible PhD projects will involve 1) identifying the patterns of activity in individual neurons in the brain that correlate with the formation of specific memories and/or the selection of specific actions, using light-sheet and two-photon imaging of neural activity or patch-clamp recordings; 2) testing whether the candidate neurons are required and sufficient for learning and action selection by manipulating them using optogenetics or thermogenetics in freely behaving animals; 3) identifying genes required for learning and memory in specific neurons using RNAseq and testing whether they are required using targeted knockdown.
Funding Notes
See the Laboratory of Molecular Biology funding information for details.
References
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