Coupled chemical oscillations in networks of neurons and astrocytes

About the Project

Project Overview:

Waves and oscillations of molecules play a critical role in information processing in the brain. Meanwhile, pulsatility of hormones is the foundation of fertility, emotional regulation and mammalian behaviour. This project offers an exciting opportunity to understand how estrogen, calcium waves and neuronal activity are connected in rhythmic cycles of activity. We want to explore how estrogen can affect astrocyte-neuron communication during Ca2+ exchanges and oscillations at synapses. Links of Ca2+ oscillations to actin polymerization/depolymerization driven by estrogen will also be investigated. This allows not only for understanding of the relevance of rhythm in biological systems but also provides an opportunity to understand how pathological states may disrupt biology by altering the underlying rhythms.

Skill training and opportunities

The project offers excellent opportunities for training and development. You will develop skills in data analysis, delivering poster and powerpoint presentations in conferences, and writing scientific publications. Biological techniques that will be learned include qPCR, immunohistochemistry, confocal microscopy, acute slice work using a novel technique for gathering viable slices, possible ELISA and electrophysiology. The student can also network with a vibrant group studying hormonal and neuronal function both in normal physiological states and disease.

Neural Models Group:

Our group uses models of the central nervous system to understand the brain and treat pathologies. We use stem cells, brain slices and primary cells to engineer neural networks that are examined under different conditions, and characterized using techniques such as PCR, electrophysiology and immunohistochemistry.

University of Reading:

The University of Reading, located west of London, England, provides world-class research education programs. The University’s main Whiteknights Campus is set in 130 hectares of beautiful parkland, a 30-minute train ride to central London and 40 minutes from London Heathrow airport.

Our School of Biological Sciences conducts high-impact research, tackling current global challenges faced by society and the planet. Our research ranges from understanding and improving human health and combating disease, through to understanding evolutionary processes and uncovering new ways to protect the natural world. In 2020, we moved into a stunning new ~£60 million Health & Life Sciences building. This state-of-the-art facility is purpose-built for science research and teaching. It houses the Cole Museum of Zoology, a café and social spaces.

In the School of Biological Sciences, you will be joining a vibrant community of ~180 PhD students representing ~40 nationalities. Our students publish in high-impact journals, present at international conferences, and organise a range of exciting outreach and public engagement activities.

During your PhD at the University of Reading, you will expand your research knowledge and skills, receiving supervision and training in a number of different forms. We also provide dedicated training in important transferable skills that will support your career aspirations. If you need to develop your academic English skills before you start your studies, then the University has an excellent International Study and Language Institute which can help with this.

The University of Reading is a welcoming community for people of all faiths and cultures. We are committed to a healthy work-life balance and will work to ensure that you are supported personally and academically.

Eligibility:

• Applicants should have a good bachelor’s degree (minimum of a UK Upper Second (2:1) or equivalent)/master’s degree in Biomedical Engineering or a strongly-related discipline.
• International applicants will also need to meet the University’s English Language requirements. We offer pre-sessional English courses that can help with meeting these requirements. With a commitment to improving diversity in science and engineering, we encourage applications from underrepresented groups

The University of Reading is committed to a policy of equal opportunities and non-discriminatory treatment for all members of its community.

How to apply:

Submit an application for a PhD in Biomedical Engineering via our online application system.

Funding Notes

We welcome applications from self-funded students worldwide for this project.

If you are applying to an international funding scheme, we encourage you to get in contact as we may be able to support you in your application.