"Cryo EM/ET Research Associate"

Berkeley Lab's Molecular Biophysics and Integrated Bioimaging Division has an opening for a Research Associate to perform semi-routine research assignments, including the development of deep learning-based denoising frameworks and sub-tomogram alignment for cryo-electron tomography datasets, to support the analysis of the performance of various denoising algorithms. This role will assist with developing and testing segmentation-based tools for the alignment of X-ray tomography data. This position has an anticipated start date of September 1, 2025.

What You Will Do:

• Test cryoCARE, IsoNET, deepDeWedge, and Topaz for denoising and missing-data compensation in simulated and experimental cryoET data.
• Run sub-tomogram alignment and averaging for reconstruction of 3D density on the datasets.
• Assist in developing segmentation-based tools for alignment of center-of-rotation and tilt of rotation axis in X-ray tomography data.
• Maintain an accurate and detailed scientific notebook of all numerical experiments performed and document results for a publication.
• Assist in developing spatial redundancy transformers for denoising.

What is Required:

• A Bachelor's Degree (or equivalent knowledge/training) in Applied Mathematics, Computer Science, Computational Biology, or related field and a minimum of 1 year of experience with basic coding skills in Python and pyTorch or an equivalent combination of education and experience.
• Familiarity with the theory of tomography and microscopy.
• Familiarity with analysis software for Cryo EM/ET (Relion, IMOD, STA).
• Strong oral and written communication skills, including the ability to maintain detailed and accurate laboratory documents and records.
• Effective interpersonal skills include the ability to work independently and collaboratively in a multidisciplinary laboratory environment.

Notes: This is a full time, non-exempt from overtime (hourly paid), 6 month, Term appointment with the possibility of extension or conversion to Career appointment based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. Salary for this position will be commensurate with the final candidate's qualification and experience, including skills, knowledge, relevant education, certifications, and aligned with the internal peer group. This position will be performed onsite at Lawrence Berkeley National Lab, located at 1 Cyclotron Road, Berkeley, CA 94720.