Deciphering critical regulators in wheat rust immunity

immune signaling against biotrophic pathogens. We previously showed in bread wheat (Triticum aestivum), that infection by the biotrophic yellow rust pathogen (Puccinia striiformis f. sp. tritici; Pst) upregulates the gene for BCAA AMINOTRANSFERASE 1 (TaBCAT1), which modulates catabolism of BCAAs to prevent BCAA accumulation and promote Pst colonisation. In contrast, disrupting TaBCAT1 function leads to hyperaccumulation of BCAAs and SA, resulting in reduced susceptibility to Pst. Furthermore, we found that BCAA-mediated SA accumulation is dependent on a MYB/SANT transcription factor (TF), termed TaASIL1, which represses expression of TaSIZ1, a SUMO E3 ligase that is a key negative regulator of SA homeostasis. However, how BCAA accumulation enhances TaASIL1 activity remains to be resolved.

The aim of this proposal is to elucidate how BCAA availability activates SA-mediated defence and/or modulates metabolic signalling in plants, by: (i) resolving the unknown link between BCAA accumulation and activation of TaASIL1 function, and (ii) characterising additional BCAA-dependant gene targets of TaASIL1. This research will ultimately determine how MYB TFs mediate environmental signals, such as BCAAs, to modulate metabolic signalling in plants and provide critical new insight into basal plant defence responses in wheat.

The student will be embedded in the Saunders Lab at the John Innes Centre, which is a multidisciplinary research lab, providing the opportunity to develop extensive skills in a breadth of areas, including plant pathology, wheat genetics, molecular biology, and bioinformatics.

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2027 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team.

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on the 2nd, 3rd and 4th February 2027.

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.

To maximise accessibility and attract students from underrepresented groups to our programme we have introduced bespoke templates for applicant Personal and Research statements which will enable every applicant to fully represent themselves through providing suitable examples and evidence. These forms are on the NRPDTP website and must be used for these sections of the application form.

Entry requirements

At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).

Mode of study

Full-time

Start date

1 October 2027

Funding Notes

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.