Democratising Prenatal Screening: Evaluating finger prick Dried Blood Spots as a Simplified Alternative to Plasma-Based Non-Invasive Prenatal Testing for Common Aneuploidies

About the Project

SLS-2. Democratising Prenatal Screening: Evaluating finger prick Dried Blood Spots as a Simplified Alternative to Plasma-Based Non-Invasive Prenatal Testing for Common Aneuploidies.

We are seeking a highly motivated PhD candidate to pioneer a simplified approach to non-invasive prenatal testing (NIPT) for fetal chromosomal abnormalities. This innovative project investigates alternative sources of DNA, such as blood spot samples, that could potentially replace blood plasma for accurate detection of common trisomies (Down's, Edwards', and Patau syndromes), potentially revolutionising prenatal screening accessibility worldwide.

You will develop and validate a novel NIPT assay using cutting-edge molecular techniques, including next-generation sequencing (NGS), cell-free DNA (cfDNA) extraction, and fetal fraction quantification. This combined wet-lab and dry-lab project offers hands-on experience with advanced genomic technologies while conducting a comprehensive cost-effectiveness analysis to assess the feasibility of implementing blood-spot screening in clinical settings. The research addresses a critical healthcare challenge: current plasma-based NIPT requires specialised equipment, trained phlebotomists, and cold-chain transport, limiting accessibility in resource-constrained settings. Your work could enable self-collection, reduce NHS costs, and democratize access to gold-standard prenatal screening globally.

REQUIREMENTS: Undergraduate degree (or equivalent) in molecular biology, genetics, bioinformatics, or related biomedical sciences. Strong organizational skills and meticulous attention to detail. Commitment to completing mandatory Human Tissue Act (HTA) training. Enthusiasm for collaborative research with clinical partners

DESIRABLE SKILLS: Experience in omics technologies or bioinformatics data analysis. Knowledge of prenatal diagnostics or reproductive health. Statistical analysis experience. Note: Training in NGS, cfDNA analysis, and data interpretation will be provided during Year 1.

This research directly contributes to UN Sustainable Development Goals (SDG 3: Good Health and Well-being, SDG 5: Gender Equality, SDG 10: Reduced Inequalities) by developing accessible diagnostic tools that empower women to make informed reproductive decisions. By simplifying prenatal screening, you will help eliminate healthcare disparities and improve maternal-fetal outcomes in underserved communities. Join us in transforming women's health through innovative biomedical research that bridges laboratory science and real-world clinical impact. This is your opportunity to develop expertise in advanced molecular diagnostics while addressing a critical global healthcare need.

Please contact Dr Maria Neofytou to discuss: m.neofytou@westminster.ac.uk

The studentships will include comprehensive personal and professional development training and a mentoring programme from the University of Westminster Graduate School. The researchers will join a School committed to decolonising and diversifying policies, practices and cultures within and beyond Higher Education.

Entry requirements and how to apply.

Candidates should have a minimum classification of 2.1 in their Bachelor's degree or equivalent, and preferably a Master’s degree. Applicants whose secondary level education has not been conducted in the medium of English should also demonstrate evidence of appropriate English language proficiency normally defined as IELTS: 6.5 (overall score with not less than 6.0 in any of the individual elements).

You must include the code and title of the studentship you are applying for in your application header, i.e. “SLS-2 Studentship”.

For queries about any aspect of the application process or informal enquiries, contact our Doctoral Coordinator, Dr Polly Hayes: p.hayes@westminster.ac.uk