Designer photoenzymes for selective C-H functionalisations

About the Project

A PhD studentship is available in the groups of Dr Florence Hardy and Prof Anthony Green, University of Manchester, as part of the cross-institutional BioAID Doctoral Training Programme.

Project Summary: This studentship will focus on designing photoenzymes for enantioselective C-H functionalization chemistry using the latest deep learning tools for protein design. We will design photoenzymes to catalyse the 4-pyridination of benzylic Csp3–H bonds using advanced computational enzyme design techniques.

Through this project, the student will receive training in enzyme design and protein structure prediction, organic synthesis, biocatalysis, and directed evolution.