Developing an optimized pgSIT system to control important agricultural insect pests
About the Project
This is a co-funded industry PhD studentship embedded in a collaborative partnership between Imperial College London and Agragene Inc.
Agricultural insect pests cause major crop losses worldwide. The Precision-Guided Sterile Insect Technique (pgSIT) is an emerging CRISPR-based technology. This project will improve pgSIT performance by refining CRISPR construct design, enhancing promoter specificity, and identifying gene targets.
The studentship
- Optimise pgSIT genetic construct design
- Identify promoter and gene-target combinations
- Evaluate the genetic, physiological and developmental effects
- Develop engineering strategies to improve transgene stability
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