Dissecting Microglia–Astrocyte Crosstalk in Amyotrophic Lateral Sclerosis Using Human Stem Cell Models

About the Project

Applications are invited for a fully funded PhD studentship within the Institute of Medical Sciences at the University of Aberdeen, commencing in October 2026. This project offers an exciting opportunity to investigate the cellular and molecular mechanisms underpinning amyotrophic lateral sclerosis (ALS), with a particular focus on neuroinflammatory processes.

ALS (also known as motor neuron disease) is a rapidly progressive neurodegenerative disorder leading to paralysis and ultimately death. Despite significant advances in understanding neuronal vulnerability, ALS remains incurable. Increasing evidence highlights the critical role of non-neuronal cells, particularly microglia and astrocytes, in driving ALS disease processes through neuroinflammatory pathways^{1, 2}.

This project will focus on understanding the interplay between microglia, the resident immune cells of the central nervous system, and astrocytes in ALS. Our previous work established the first protocol for co-culturing human induced pluripotent stem cell (iPSC)-derived microglia with motor neurons³, demonstrating that microglia from ALS patients induce motor neuron death⁴. Emerging data from our group further suggest that ALS patient microglia release signalling molecules that activate astrocytes, which in turn will likely cause neurotoxicity⁵. These findings point to a potentially critical pathogenic axis involving microglia–astrocyte crosstalk.

Building on this foundation, the PhD student will use a fully human, stem cell–based model system to dissect the complex interactions between motor neurons, microglia, and astrocytes. By integrating single-cell transcriptomics, high-throughput imaging, and advanced co-culture approaches, the project aims to uncover key mechanisms by which neuroinflammatory signalling drives neuronal degeneration. The outcomes are expected to provide important insights into ALS pathogenesis and identify novel avenues for therapeutic intervention.

The successful candidate will receive comprehensive training in cutting-edge techniques, including human iPSC culture and differentiation, single-cell RNA sequencing, high-content imaging, and advanced microscopy. The student will gain additional valuable skills in experimental design, data analysis, and scientific communication, joining a dynamic and collaborative research environment.

Informal enquiries are encouraged. For further information please contact Dr Björn Vahsen (bjorn.vahsen@ndcn.ox.ac.uk)

Candidate Background

Candidates must have or expect to obtain a 1st class honours or an upper 2:1 in their undergraduate degree in in a relevant discipline such as neuroscience, biology, biomedical sciences, or a related field, as well as a significant level of wet-lab research experience in biology or a related field.

Candidates should have a strong interest in neurobiology and neurodegenerative disease, with a particular enthusiasm for understanding cellular and molecular mechanisms of disease. Prior laboratory experience in cell culture and molecular biology/neuroscience techniques is essential. Experience with stem cell models, microscopy, or bioinformatics analyses (e.g. RNA sequencing) would be beneficial but is not required, as full training will be provided.

Applicants should demonstrate strong analytical and problem-solving skills, attention to detail, and the ability to work both independently and as part of a team. Good communication skills and a proactive approach to learning are essential.

Promoting equality, diversity, and inclusion is at the heart of the University of Aberdeen. We welcome applicants from all backgrounds and actively encourage applications from people with diverse career paths, regardless of age, disability, ethnicity, gender, sexual orientation, or other protected characteristics.

Application Procedure

Important note: This project is open only to applicants eligible for the Home/UK fee rate. This includes EU students who hold settled or pre-settled status and meet the relevant residency criteria.

To apply, please submit the following documents via email to smmsn-pgrenquiries@abdn.ac.uk

• A cover letter addressed to the supervisor of the project you're applying for.
• An up-to-date CV detailing your academic qualifications, employment history, and any other relevant experience. Please ensure your current permanent address is clearly stated, as this will be used to determine your fee status.
• Clear copies of your degree certificates and transcripts (if available).
• Evidence of settled or pre-settled status (if applicable).

Please send your application with documents attached as a single email with the subject line: "Bjorn Vahsen PhD Studentship - [Your Name]"

The deadline for applications is 23:59 GMT on 9th June 2026. Please note that incomplete applications will not be considered.

For any enquiries regarding your application or the application process, please contact smmsn-pgrenquiries@abdn.ac.uk

Funding Notes

This PhD studentship is fully funded by the Margaret Carlaw Trust for 3.5 years. The award includes an annual tax-free stipend (set at £21,416 for the 2026/2027 academic year), Home/UK tuition fees, and an allowance for research consumables.

The anticipated start date is October 2026.