About the Project
Developmental signalling cues drive major chromatin and transcriptional changes, via the combined action of transcription factors and chromatin effectors. However, it remains unclear how such signalling cues induce the earliest chromatin changes that commit cells to differentiation. We have established a system in human induced pluripotent stem cells (iPSCs) to investigate the mechanisms of cell fate transitions in replicating cells and open this area for exploration. We recently identified a…
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