Doctoral Candidate DC3

immunotherapy and the necessary transferable skills. CanGoNano will provide an international, intersectoral and interdisciplinary educational program, according to the EU Principles for Innovative Doctoral Training. This will put DCs in an advantageous position for job opportunities in both academia and industry

Within the CANGONANO network, the University of Florence (UNIFI) is recruiting 1 Doctoral Candidate (DC) to carry out research in GlycoNanoMaterials for precision delivery of genetic material to antigen presenting cells. The positions will be supervised by Prof. Barbara Richichi and Prof. Marco Marradi at UNIFI, and will offer candidates the opportunity to work at the forefront of glyconanotechnology to fill gaps in cancer immunotherapy, while benefiting from tailored training and international secondments across the consortium.

Doctoral Candidate DC3:

Project Title: Glycosylated polycation cellulose nanocrystals and mRNA polyplexes for the precision delivery of genetic material to antigen presenting cells.

Project: This PhD project will focus on: 1) Synthesis of polycationic pCNC with quaternary ammonium groups; 2) Multiple functionalization of pCNC with amine-bearing carbohydrate fragments / fluorescent probes via carbamate chemistry; 2) Synthesis and physicochemical characterization of pCNC/mRNA polyplexes; 3) Evaluation of the immunogenicity of pCNC/mRNA polyplexes; 4) Training in synthesis and characterization of pCNC-based polyplexes, advanced microscopy, antibody isotyping and T cell culture.

Host Institution: Department of Chemistry 'Ugo Schiff', University of Florence (UNIFI), Italy. https://www.chim.unifi.it/

Duration: 36 months, starting from 01/11/2026 to 01/02/2027

Supervisor: Barbara Richichi (UNIFI, IT). https://cercachi.unifi.it/p-doc2-0-0-A-3f2b342b392c2f.html

Co-supervisors: Maria Elisa Perico (APTUIT, IT), Sandra van Vliet (AUMC, NL), Marco Marradi (UNIFI, IT)

PLANNED SECONDMENTS. (1) AUMC, S. van Vliet, (II year, 2M), training on the cross-talk between APCs and T-cells; (2) APT, M. E. Perico (III year, 2M), training in immunogenicity of GNM in vivo.

PhD School enrolment: Chemical Science at the University of Florence (https://www.dottoratoscienzechimiche.unifi.it/index.html)

Where to apply

Website: https://cangonano.eu/

Requirements

Research Field: Chemistry » Organic chemistry

Education Level: Master Degree or equivalent

Skills/Qualifications

• Master Degree (M.Sc. degree) in Chemistry, Pharmaceutical Chemistry, Biotechnology, (Nano)Materials Science and strictly related ones
• Practical experience in organic and materials chemistry, and characterization techniques
• Good level of English proficiency
• Team spirit and pro-active attitude

Specific Requirements

The selected candidate must meet the following requirements:

• Commit full-time to the research activity, unless authorization is granted by the European Commission for personal or family reasons.
• Carry out exclusively the research activities related to the specified research program, and refrain from undertaking any teaching activities at the university.
• Refrain from receiving any additional income beyond what is specified in the call.
• Agree to sign all necessary agreements concerning intellectual property rights.
• Maintain confidentiality in accordance with the regulations of the European Project.

Languages: ENGLISH

Level: Good

Research Field: Chemistry » Organic chemistry

Internal Application form(s) needed: CanGoNano_Call for DC3.pdf (English, 533.87 KB - PDF)

Additional Information

Benefits

Each recruited Doctoral Candidate will be offered a temporary gross research fellowship. The salary of the doctoral candidates (DCs) will be paid in accordance with the MSCA rules. Please, refer to the section “Applicable Unit Contributions” (page 118 and following) of the Horizon Europe Work Programme 2023-2025 for MSCA-DN actions, available at the following link: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/wp-call/2023-2024/wp-2-msca-actions_horizon-2023-2024_en.pdf

Please, refer to the above-mentioned link and the MSCA-DN dedicated webpage (https://marie-sklodowska-curie-actions.ec.europa.eu/actions/doctoral-networks).

Eligibility criteria

The position is open to candidates of any nationality, provided they strictly fulfil the eligibility requirements established for the enrollment through the Marie Sklodowska-Curie Action-Doctoral Network (MSCA-DN). Equal opportunities policy without distinction on the grounds of gender, racial or ethnic origin, religion or belief, disability, age or sexual orientation will be applied. Please, refer to the section “Recruited Researchers” (page 122 and following) of the Horizon Europe Work Programme 2023-2025 for MSCA-DN actions, available at the following link: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/wp-call/2023-2024/wp-2-msca-actions_horizon-2023-2024_en.pdf

In particular, at the time of recruitment, applicants must comply with the following eligibility criteria:

➢ Experience: Applicants must not be already in possession of a doctoral degree. Applicants who have successfully defended their doctoral thesis, but who have not yet formally been awarded the doctoral degree, will not be considered eligible. Applicants must possess a five-years university degree (Master’s degree or equivalent).

➢ Mobility rule: Applicants must not have resided or carried out their main activity (work, studies, etc.) in the country where the research training activities will take place for more than 12 months in the 3 years immediately prior to the recruitment date.

Selection process

APPLICATION PROCEDURE

The applicant must apply through the project website: www.cangonano.eu. Any other form of application will not be considered.

All applications will be checked for eligibility. Incomplete applications will be ignored. Applications will be in English. Applicants must complete/upload the data/documents and information through the project website www.cangonano.eu by following an 8-step application procedure.

ASSESSMENT CRITERIA / EVALUATION CRITERIA

Supervisors will pre-select candidates for each position, based on the information included in the application procedure that will be evaluated against the following criteria:

- Educational record;

- scientific quality of the applicant’s CV;

- expected individual impact and benefit to the fellow and to the project;

- previous experience in the subject of the CanGoNano research programme.

Shortlisted candidates will be invited for interviews with multiple supervisors from the network (online or in-person). Good level of English proficiency (understood, spoken and written) will be considered. Candidates will be notified of the outcome via the website.

Additional comments

The start of the employment is foreseen between the 1st November 2026 and the 1st February 2026, in accordance with the local regulations of the recruiting institution and in agreement with the local supervisors. Doctoral candidates must be enrolled in a doctoral programme leading to the award of a doctoral degree in at least one EU Member State or Horizon Europe Associated Country.

Candidates must meet all admission requirements for the PhD programme at the recruiting institution. These requirements must be fulfilled at the start of the contract.

Candidates of all nationalities and genders are welcome to apply.

In line with MSCA requirements, candidates must be willing to undertake international mobility during the fellowship, which is a mandatory requirement and may account for up to 30% of the contract duration.

Please submit your application form, including CV, motivation letter, recommendation letter(s), and copies of relevant diplomas/documents via the project website: www.cangonano.eu by using the “APPLY NOW” function

Candidates will be notified of the outcome via the website.

For questions exclusively not addressed in the application guidelines available on the project website, candidates may contact the project team at cangonano@chimica.unifi.it. Replies will be provided only in such cases.

Work Location(s)

Number of offers available: 1

Company/Institute: University of Florence

Country: Italy

State/Province: Firenze

City: Sesto Fiorentino

Postal Code: 50019

Street: Via della Lastruccia 13

Contact

State/Province: Firenze

City: Firenze

Website: http://www.unifi.it

Street: Piazza San Marco 4

Postal Code: 50121