tissue-level fluid dynamics.
This PhD will advance these MRI methods by developing approaches to map vascular-tissue fluid coupling at the voxel level. The student will design rapid measurements sensitive to blood and tissue water volume fractions, aim to map these quantities across the entire brain and determine how they change in response to physiological challenge. Physics-based models and simulations will establish which compartments can be distinguished and optimise temporal resolution, spatial detail and precision.
The methods will be tested in preclinical experiments using controlled physiological challenges and under conditions of cortical spreading depolarisation, a travelling wave of altered brain activity and blood flow. The methods will be translated to human MRI, establishing feasibility and reproducibility and laying the foundations for studies in disorders of brain fluid dysregulation (e.g. dementia, idiopathic normal pressure hydrocephalus).
This PhD project will suit a student with strong numerical skills (e.g. Physics, Maths or Engineering degree) with an interest in medical imaging, biophysics, or neuroscience. The student will receive training in MRI physics, pulse-sequence development, computational modelling and experimental neuroimaging. They will join the neuroimaging and modelling group (NiMo) and have access to state-of-the-art imaging infrastructure including brand-new 7T Bruker Maxwell preclinical MRI scanner and 3T Philips Achieva scanner with dStream upgrade.
Entry Requirements
You must hold, or be about to obtain, a minimum Upper Second Class UK honours degree, or the equivalent qualification gained outside the UK, in a relevant discipline. Previous studies in physics, engineering, or applied maths would be an advantage. A related master’s degree would be an advantage. Research experience in neuroimaging is desirable.
International applicants (including EU nationals) should ensure that they meet the academic eligibility criteria for the programme. Applicants who are offered a place will also need to meet the University's English language requirements before commencing their studies. Further information can be found on the University's English Language Requirements page.
Application Guidance
Candidates must contact the primary supervisor before applying to discuss their interest in the project and assess their suitability.
Apply directly via this link: https://tinyurl.com/mt2xfsvp or on the online application portal, select EPSRC DTP PhD as the programme of study.
You may apply for up to two projects within this scheme. If you wish to apply for two projects, you must submit a separate online application for each project, listing the relevant project title and main supervisor in each application.
Please ensure that your application includes all required supporting documents:
- Curriculum Vitae (CV)
- Supporting Statement
- Academic Certificates and Transcripts
Incomplete or late applications will not be considered. Further details are available on our website: EPSRC Doctoral Training Partnership | Biology, Medicine and Health | The University of Manchester
Equality, diversity and inclusion are central to the University’s activities. The full statement can be found here: https://www.bmh.manchester.ac.uk/study/research/getting-
Funding Notes
The EPSRC studentships provide full funding for tuition fees and a stipend at the Research Councils UK (UKRI) rate for 3.5 years starting in September 2027. Please note, candidates will need to cover the cost of relocation and any associated costs (e.g. visa, health surcharges).
