About the Project
Background: Cardiac fibrosis is often defined as the excessive production of extracellular matrix (ECM) proteins, which negatively impact the ability of the heart to contract and relax. Alongside production, the ECM undergoes extensive remodelling facilitated by metalloproteases and other ECM modifying enzymes, leading to changes to matrix crosslinking, structure and ultimately quality. Using human cardiac organoids – a live contracting 3D model incorporating many important heart cell types – we…
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