Formulation of hybrid peptide-lipid nanoparticle formulations for targeted nucleic acid delivery

About the Project

The project aims to develop next-generation delivery systems that combine the structural advantages of lipid nanoparticles with the targeting and membrane-translocating properties of peptides. While LNPs have demonstrated remarkable success in clinical mRNA delivery, their broader application is limited by challenges such as poor cell-type selectivity and inefficient endosomal escape. This project seeks to address these limitations by engineering hybrid peptide-lipid nanoparticles (PLNPs) capable of enhancing nucleic acid stability, cellular uptake, and targeted delivery. Through comprehensive physicochemical characterisation, in vitro and in vivo evaluation, the project will establish a versatile platform for gene therapy applications across a range of diseases.

Briefly describe the training that will be provided through the research project

Right from the start the PhD student will be involved in academic research designed to have translational/clinical application. This dual approach spans:

1. Research Skills: the academic supervisors will ensure excellent training in nanoparticle formulation, systematic physical characterisation, in vitro cell and molecular biology techniques and potentially in vivo skills.
2. Record keeping & monitoring: Monthly meetings with the student will take place with electronic records. Students must also complete a 3-month initial review and annual progress review to proceed to years 2 & 3. The annual progress review involves written work, presentation and/or mini viva. However, at each of these meetings, the primary supervisor will also be present ensuring that the maximal training benefit can be derived from these processes.
3. Additionally, there will be opportunities to present at academic meetings, building professional networks, personal development on courses for animal licenses, advanced statistics, skills which are all relevant to subsequent employment opportunities.

Briefly outline the expected impact activities

Impact activities include but are not restricted to presenting the research to academic and industry peers through scientific conferences and students from different disciplines through the Graduate School. The student will also engage with patients, clinicians and key stake holders through a series of webinars/focus groups to understand how they can feed and shape the research plan. Other impact activities relate to commercialisation though IP protection processes, competitor analysis and engagement with clinical collaborators.

Funding Notes

This project is not funded; applications are welcome from self-funding candidates.

References

Cell Penetrating Peptides, Gene delivery, Hybrid nanoparticles, Nanomedicine, Targeted Treatments