FULLY FUNDED PhD - Magnetotactic bacteria as living contrast agents in magnetomotive ultrasounds

About the Project

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Motivation & Context

Magnetotactic bacteria (MTB) naturally synthesise high-quality magnetic nanoparticles (“magnetosomes”) with exceptional monodispersity, crystallinity and magnetic behaviour. These properties outperform most synthetic alternatives and are increasingly attractive for biomedical imaging, actuation and diagnostics. Recent studies have demonstrated the feasibility of expressing minimal magnetosome gene sets in E. coli, enabling first-generation engineered “MagColi” capable of intracellular biomineralisation. In parallel, magnetomotive ultrasound (MMUS) is emerging as a powerful methodology to visualise magnetic nanoparticles through nanometre-scale oscillatory motion under alternating magnetic fields.

NanoEcho’s technology pipeline relies on high-performance magnetic contrast agents. A biological route to controlled nanoparticle synthesis offers a new, tuneable manufacturing strategy with strong IP potential in the domains of contrast agents, living diagnostics, and magnetic actuation. This project addresses that opportunity.

Project Aim

To develop, characterise, and engineer biological production routes for magnetic nanoparticles using magnetotactic bacteria and recombinant E. coli, and to evaluate their application as next-generation MMUS contrast agents, creating a foundation for translational IP aligned with NanoEcho.

Key References

1. Faivre and Schüler DOI 10.1021/cr078258w
2. Berny et al. DOI 10.3389/fbioe.2020.00016

Student requirements

This project is ideal for a motivated and curious student interested in microbiology, synthetic biology, and biotechnology. You will work hands-on with bacteria, using genetic engineering techniques to enable them to produce magnetic nanoparticles (magnetosomes).

You’ll gain experience in molecular biology, lab-based experimentation, and data analysis, while working on a cutting-edge research topic with real-world applications. The project is carried out in collaboration with NanoEcho, giving you exposure to industry—this includes regular interaction with the company, opportunities to present your progress, and the possibility of a placement.

We’re looking for someone who is enthusiastic, proactive, and willing to tackle challenges in a new and fast-moving field. You don’t need to know everything at the start—but a strong interest in learning, problem-solving, and pushing ideas forward is essential.

Qualifications

Life sciences degree at Honours level, with min 2.1, in relevant subjects such as microbiology, genetics or molecular biology. Ideally a Masters degree and clear lab experience of cloning or bacteriology.

Funding Notes

NanoEcho, EPSRC and the School of Infection & Immunity will cover fees, stipend and consumables for UK students only.

Project start date: 01.09.2026