FULLY FUNDED PhD - The structural and molecular basis of substrate specificity of the thioesterases APT1 and APT2

About the Project

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Project Description

A prominent protein modification found in all eukaryotic species is S-acylation, the attachment of hydrophobic acyl chains onto cysteine side chains. S-Acylation regulates the localisation, stability, interactions, and function of numerous proteins, and thereby affects cellular processes like growth, migration, differentiation, and communication. S-acylation is reversible and is regulated by many zDHHC (on) and APT/ABHD (off) enzymes, however, in contrast to many other enzymes that mediate post-translational regulation of proteins, we currently lack fundamental knowledge about these enzymes and their contribution to cell physiology. This project will provide an important advance in this area by uncovering mechanisms whereby de-S-acylation enzymes recognise their specific substrate partners.

The project will provide a broad range of training outcomes including, expertise in cutting-edge molecular and structural analyses, data analysis and team working skills, and networking and presentation skills gained through attendance at relevant conferences. There will also be training in a range of generic areas including research ethics and research integrity, data management, and responsible research.

This project will support a large multidisciplinary project with multiple partner labs across the UK, applying multidisciplinary Team Science approach to deliver fundamental new insights into the role of S-acylation in cell physiology.

You will join a dynamic and supportive team, working collaboratively across two research groups within the College of Medical, Veterinary and Life Sciences, with access to state-of-the-art facilities and mentorship tailored to your career development. Both groups have a strong track record of interdisciplinary research and publication in high-impact journals.

Candidate Profile

We are looking for a highly motivated individual with a background in molecular or structural biology, biochemistry, or a related field. Prior experience in protein biochemistry is desirable but not essential. Candidates available to start in October 2026 will be prioritised.

Application Details

Please submit a CV, cover letter, and contact details for two referees via the application portal. Informal inquiries are welcome and encouraged.

Funding Notes

UK Student fees covered.