How Do Mechanical Forces Shape Organs? Developmental Biophysics and Bioengineering of Ciliated Tissues

About the Project

We invite applications from candidates eligible for UK student status for a PhD project investigating how mechanical forces contribute to development, and how these principles can be harnessed to inspire engineering solutions for tissue repair and regenerative medicine.

Candidates with either experimental or theoretical backgrounds are encouraged to apply.

The project will focus on ciliated tissues, such as those lining the airways, where microscopic hair‑like structures called cilia beat in a coordinated manner to generate fluid flow and transport mucus. While these systems are essential for physiological function, how they self‑organise during development to establish robust, large‑scale fluid flows remains poorly understood.

This project will investigate how mechanical forces, fluid flow, and mechanotransduction drive the self‑organisation of ciliated tissues during development and wound healing.

Together, we will combine quantitative experiments and mathematical modelling to uncover the physical principles underlying fluid transport in developing tissues, with relevance to tissue repair and regenerative medicine.

Who should apply?

Applicants from biology, physics, engineering, mathematics, or related disciplines are encouraged to apply. Both students with experimental and/or quantitative experience are welcome.

Ideal for students interested in:

• bioengineering
• biosciences
• biophysics
• cell mechanics
• fluid dynamics

Training includes:

• quantitative live imaging; image analysis
• biophysical experiments, including biophysical manipulation of Xenopus embryos
• computational modelling
• microfabrication and 3D printing

Research environment

Based at Durham University, you will join a collaborative environment spanning Engineering, Biosciences, and the Durham Biophysical Sciences Institute.

You will have access to state-of-the-art imaging, fabrication, and interdisciplinary research facilities.

Funding Notes

This PhD studentship is for four years and is available to home students only. The funding covers a tax-free stipend at the UKRI rate and the full tuition fees at the home rate.

If you are interested in applying, in the first instance contact the supervisor (Francesco Boselli, francesco.boselli@durham.ac.uk), detailing your reasons for applying for the project, as soon as possible, by no later than May 30, 2026. The position will be closed as soon as it is filled.