Investigating mechanisms of impaired regeneration in aged skin

About the Project

A PhD studentship is available at Queen Mary University of London to investigate mechanisms of impaired regeneration in aged skin. With age, the skin undergoes well defined changes in the extracellular matrix, mechanics, and metabolic activity, which together give rise to a loss of resiliency and healing capacity. This project aims to employ multi-omic analyses to dissect the cellular and molecular mechanisms that contribute to skin ageing, with a particular focus on the role of cellular senescence in dermal fibroblasts. In addition, the project will take advantage of advanced 3D in vitro skin models to test key regulatory processes within physiologically relevant conditions.

The studentship will be based in Prof. John Connelly’s lab in the Blizard Institute, which is a modern biomedical research institute with outstanding facilities and equipment. The Connelly lab is also part of the Centre for Cell Biology and Cutaneous Research, which is a leading centre for skin biology and dermatology research in the UK. Full funding is available for three years and will cover a tax-free stipend (£22,780 p.a.), home or international fees, and consumables. Interviews will take place in July, and the studentship will begin in October 2026.