Investigating the Impact of Incretin-Mimetic Drugs on Chemotherapy Response in Obesity-Driven Cancers

About the Project

Incretin-mimetic drugs (IMDs) have gained widespread attention as promising therapies for managing type 2 diabetes and obesity. Recently approved by NICE, EMA, and FDA, these drugs are rapidly becoming part of routine care for obese patients. However, as their use expands, they are increasingly likely to interact with obesity-associated cancers, raising critical questions about their influence on cancer treatment outcomes.

This PhD project addresses an urgent and unexplored area: how IMDs may alter chemotherapy response in obesity-driven cancers. The study will explore whether these drugs enhance or hinder the effectiveness of standard chemotherapy, and uncover the molecular mechanisms behind these interactions.

Research Objectives

In Vitro Screening: Using 13 cancer cell models, we will assess how physiological concentrations of IMDs affect chemotherapy response. High-throughput assays—including MTT viability tests, drug accumulation/efflux assays, and wound healing assays – will be employed to quantify changes in cell fate.

Mechanistic Insights: We will identify and validate molecular pathways influenced by IMDs that contribute to chemoresistance or chemosensitivity. Techniques such as CRISPR/Cas9 gene editing, mRNA sequencing, and In/On-Cell Western assays will be used to dissect these pathways.

In Vivo Validation: Selected cancer models will be used to evaluate the impact of IMDs on chemotherapy efficacy in vivo, providing translational insights into their potential risks or benefits in clinical oncology.

Why Join This Project?

This is a unique opportunity to work at the intersection of metabolic disease and cancer biology, contributing to a rapidly evolving field with direct clinical relevance. You’ll gain hands-on experience with cutting-edge molecular biology techniques, high-throughput screening, and translational cancer research. The findings could inform future treatment guidelines and improve outcomes for patients with obesity-related cancers.

For information on how to apply, please visit the institution website.

Funding Notes

This is not a funded project, but you can apply for funding separately. Self-funding students are also welcome to apply.

For more information please visit the institution website.