Investigating the Multifunctional Role of NME4 in Mitochondrial Dynamics and Inflammasome Activation for Innate Immune Responses

About the Project

Mitochondria are not only the powerhouses of the cell but also key regulators of innate immunity, influencing processes such as inflammasome activation, reactive oxygen species (ROS) production, and metabolic reprogramming. NME4, also known as nucleoside diphosphate kinase D (NDPK-D) or NM23-H4, is a mitochondrial enzyme that plays a pivotal role in linking mitochondrial homeostasis to innate immune signalling. This PhD project proposes to explore NME4’s dual functions in nucleotide metabolism and mitochondrial dynamics, and how these mechanisms regulate innate immune signalling in response to microbial threats such as lipopolysaccharide (LPS). By employing genetic knockout models, advanced imaging, and metabolic profiling, the project aims to uncover novel therapeutic targets for inflammatory diseases like sepsis. The research will span cellular, molecular, and in vivo studies, contributing to our understanding of mitochondria as central hubs in immunity.

Funding Notes

This project is open to applicants who have the funding to support their own studies or who have a sponsor who will cover these costs. Note there will be a fee enhancement of £15,000 this will be charged per year.