Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health, a world-class academic medical center.
The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.
Lee Lab Postdoctoral Associate – Radiation-induced tissue injury and regeneration
The Lee lab in the Department of Radiation Oncology at Duke University is seeking a highly motivated and independent scientist for a full-time Postdoctoral Associate position in the field of normal tissue injury from ionizing radiation exposure.
This NIH-funded position will study acute and delayed injury of the intestines and oral mucosa induced by radiation, focusing on mechanisms of regenerative reprogramming and stromal-epithelial interactions.
Complementary approaches will be used, including genetically engineered mouse models, histopathology, mouse and human organoids, CRISPR-Cas9 gene editing, single-cell sequencing, and spatial transcriptomics.
A PhD, MD, MD/PhD, or equivalent degree in biomedical sciences-related fields and a track record of publications in peer-reviewed journals are required.
Experience and expertise in analyzing single-cell sequencing data are preferred.
This candidate must be detail-oriented and well-organized, with strong communication skills and the ability to work in a fast-paced, interactive team environment.
Job Description / Work to be Performed
- Perform various in vivo and in vitro experiments to dissect molecular and cellular mechanisms underlying acute epithelial injury and delayed fibrosis following high-dose radiation exposure
- Assist with maintaining lab mouse colony: set up crosses, perform tail clip biopsies, mark mice (tattoo, ear tag, etc.), and wean pups
- Collect, analyze, manage, and interpret data and prepare reports
- Prepare manuscripts for publication in peer-reviewed journals
- Contribute to writing research grants and contracts
- Assist with managing IACUC, IRB, and IBC protocols as well as lab safety SOPs
- Must be flexible to work on weekends or shifts
